Abstract
Ototoxicity is characterized by tinnitus, hearing loss and vestibular complaints. Systemically administered ototoxic drugs are: Aminoglycosides, platina-based chemotherapeutic drugs, loop diuretics, salicylates, non-steroidal anti-inflammatory drugs, quinine en erythromycin. Despite the different ototoxic mechanisms of these drugs, abnormalities in the cochlea and in particular in the outer hair cells are found. Ototoxicity may be prevented by pharmacokinetic control and maybe by administration of protective drugs. Furthermore, early detection can be done by audiologic monitoring.
| Translated title of the contribution | It often starts with tinnitus: Ototoxicity of systematically applied medicines |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 485-488 |
| Number of pages | 4 |
| Journal | Pharmaceutisch Weekblad |
| Volume | 136 |
| Issue number | 14 |
| Publication status | Published - 6 Apr 2001 |
| Externally published | Yes |
Keywords
- Adverse effects
- Cochlea
- Dose-response relationship
- Hearing disorders
- Ototoxicity