Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage

F. P.J.G. Lafeber; P. M.Vander Kraan; O. Huber-Bruning; W. B.Vanden Berg Berg; J. W.J. Bijlsma

doi:10.1093/rheumatology/32.4.281

Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage

F. P.J.G. Lafeber^*, P. M.Vander Kraan, O. Huber-Bruning, W. B.Vanden Berg Berg, J. W.J. Bijlsma

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

61 Citations (Scopus)

Abstract

Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in proteoglycan content. In this study we demonstrate that transforming growth factor β (TGFβ) a multi-functional growth factor, stimulates the proteoglycan synthesis of explants from human articular knee cartilage dose-dependently in vitro. Osteoarthritic cartilage proved to be much more sensitive to stimulation by TGFβ than normal healthy cartilage. This may indicate that TGFβ plays an important role in the repair of osteoarthritic cartilage.

Original language	English
Pages (from-to)	281-286
Number of pages	6
Journal	Rheumatology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1093/rheumatology/32.4.281
Publication status	Published - 1 Apr 1993

Keywords

Cartilage
Connective tissue
Human
Osteoarthritis
Proteoglycans
TGFβ

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title = "Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage",

abstract = "Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in proteoglycan content. In this study we demonstrate that transforming growth factor β (TGFβ) a multi-functional growth factor, stimulates the proteoglycan synthesis of explants from human articular knee cartilage dose-dependently in vitro. Osteoarthritic cartilage proved to be much more sensitive to stimulation by TGFβ than normal healthy cartilage. This may indicate that TGFβ plays an important role in the repair of osteoarthritic cartilage.",

keywords = "Cartilage, Connective tissue, Human, Osteoarthritis, Proteoglycans, TGFβ",

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AU - Lafeber, F. P.J.G.

AU - Kraan, P. M.Vander

AU - Huber-Bruning, O.

AU - Berg, W. B.Vanden Berg

AU - Bijlsma, J. W.J.

PY - 1993/4/1

Y1 - 1993/4/1

N2 - Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in proteoglycan content. In this study we demonstrate that transforming growth factor β (TGFβ) a multi-functional growth factor, stimulates the proteoglycan synthesis of explants from human articular knee cartilage dose-dependently in vitro. Osteoarthritic cartilage proved to be much more sensitive to stimulation by TGFβ than normal healthy cartilage. This may indicate that TGFβ plays an important role in the repair of osteoarthritic cartilage.

AB - Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in proteoglycan content. In this study we demonstrate that transforming growth factor β (TGFβ) a multi-functional growth factor, stimulates the proteoglycan synthesis of explants from human articular knee cartilage dose-dependently in vitro. Osteoarthritic cartilage proved to be much more sensitive to stimulation by TGFβ than normal healthy cartilage. This may indicate that TGFβ plays an important role in the repair of osteoarthritic cartilage.

KW - Cartilage

KW - Connective tissue

KW - Human

KW - Osteoarthritis

KW - Proteoglycans

KW - TGFβ

UR - https://www.scopus.com/pages/publications/0027406333

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M3 - Article

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AN - SCOPUS:0027406333

SN - 1462-0324

VL - 32

SP - 281

EP - 286

JO - Rheumatology

JF - Rheumatology

IS - 4

ER -

Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage

Abstract

Keywords

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