Osteoarthritic human cartilage is more sensitive to transforming growth factor β than is normal cartilage

F. P.J.G. Lafeber*, P. M.Vander Kraan, O. Huber-Bruning, W. B.Vanden Berg Berg, J. W.J. Bijlsma

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

61 Citations (Scopus)

Abstract

Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in proteoglycan content. In this study we demonstrate that transforming growth factor β (TGFβ) a multi-functional growth factor, stimulates the proteoglycan synthesis of explants from human articular knee cartilage dose-dependently in vitro. Osteoarthritic cartilage proved to be much more sensitive to stimulation by TGFβ than normal healthy cartilage. This may indicate that TGFβ plays an important role in the repair of osteoarthritic cartilage.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalRheumatology
Volume32
Issue number4
DOIs
Publication statusPublished - 1 Apr 1993

Keywords

  • Cartilage
  • Connective tissue
  • Human
  • Osteoarthritis
  • Proteoglycans
  • TGFβ

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