Organs by design: Can bioprinting meet self-organization?

Ivan Martin*, Jos Malda, Nicolas C. Rivron

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose of reviewEngineering functional organs starting from stem or progenitor cells holds promise to address the urgent need for organ transplants. However, to date, the development of complex organ structures remains an open challenge.Recent findingsAmong multiple approaches to organ regeneration that are being investigated, two main directions can be identified, namely the patterned deposition of cells to impose specific structures, using bioprinting technologies, and (ii) the spontaneous development of organoids, according to principles of self-organization. In this review, we shortly describe the advantages and limitations of these paradigms and we discuss how they can synergize their positive features to better control and robustly develop organs from stem cells, toward organogenesis by design.SummaryThe outlined possibilities to bring together tools and concepts of bioprinting and self-organization will be relevant not only to generate implantable organs, but also to dissect fundamental mechanisms of organogenesis and to test therapeutic strategies in modeled pathological settings.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalCurrent Opinion in Organ Transplantation
Issue number5
Publication statusPublished - 1 Oct 2019


  • organ engineering
  • organogenesis
  • regenerative medicine
  • tissue engineering


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