Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach

Sacha Spelier; Karin de Winter-de Groot; Natascha Keijzer-Nieuwenhuijze; Yves Liem; Kors van der Ent; Jeffrey Beekman; Lieke S. Kamphuis

doi:10.1183/13993003.00770-2023

Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach

Sacha Spelier
, Karin de Winter-de Groot
, Natascha Keijzer-Nieuwenhuijze
, Yves Liem
, Kors van der Ent
, Jeffrey Beekman
, Lieke S. Kamphuis

Research output: Contribution to journal › Letter › Academic › peer-review

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Original language	English
Article number	2300770
Journal	The European respiratory journal
Volume	63
Issue number	1
Early online date	19 Oct 2023
DOIs	https://doi.org/10.1183/13993003.00770-2023
Publication status	Published - 1 Jan 2024

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10.1183/13993003.00770-2023Licence: CC BY-NC

2300770.fullFinal published version, 327 KBLicence: CC BY-NC

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Spelier, S., de Winter-de Groot, K., Keijzer-Nieuwenhuijze, N., Liem, Y., van der Ent, K., Beekman, J., & Kamphuis, L. S. (2024). Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach. The European respiratory journal, 63(1), Article 2300770. https://doi.org/10.1183/13993003.00770-2023

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title = "Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach",

author = "Sacha Spelier and \{de Winter-de Groot\}, Karin and Natascha Keijzer-Nieuwenhuijze and Yves Liem and \{van der Ent\}, Kors and Jeffrey Beekman and Kamphuis, \{Lieke S.\}",

year = "2024",

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doi = "10.1183/13993003.00770-2023",

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Spelier, S , de Winter-de Groot, K, Keijzer-Nieuwenhuijze, N, Liem, Y , van der Ent, K , Beekman, J & Kamphuis, LS 2024, 'Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach', The European respiratory journal, vol. 63, no. 1, 2300770. https://doi.org/10.1183/13993003.00770-2023

Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach. / Spelier, Sacha ; de Winter-de Groot, Karin; Keijzer-Nieuwenhuijze, Natascha et al.
In: The European respiratory journal, Vol. 63, No. 1, 2300770, 01.01.2024.

Research output: Contribution to journal › Letter › Academic › peer-review

TY - JOUR

T1 - Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin

T2 - a personalised approach

AU - Spelier, Sacha

AU - de Winter-de Groot, Karin

AU - Keijzer-Nieuwenhuijze, Natascha

AU - Liem, Yves

AU - van der Ent, Kors

AU - Beekman, Jeffrey

AU - Kamphuis, Lieke S.

PY - 2024/1/1

Y1 - 2024/1/1

UR - https://www.scopus.com/pages/publications/85183585415

U2 - 10.1183/13993003.00770-2023

DO - 10.1183/13993003.00770-2023

M3 - Letter

C2 - 37857424

SN - 0903-1936

VL - 63

JO - The European respiratory journal

JF - The European respiratory journal

IS - 1

M1 - 2300770

ER -

Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach

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