Oral tobramycin prophylaxis prior to colorectal surgery is not associated with systemic uptake

T. Mulder; M. F.Q. Kluytmans-Van Den Bergh; Rogier M P H Crolla; A A M Ermens; J Romme; Nils E. Van'T Veer; J. A.J.W. Kluytmans

doi:10.1128/AAC.01723-17

Oral tobramycin prophylaxis prior to colorectal surgery is not associated with systemic uptake

T. Mulder^*, M. F.Q. Kluytmans-Van Den Bergh, Rogier M P H Crolla, A A M Ermens, J Romme, Nils E. Van'T Veer, J. A.J.W. Kluytmans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.

Original language	English
Article number	e01723
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	1
DOIs	https://doi.org/10.1128/AAC.01723-17
Publication status	Published - 1 Jan 2018

Keywords

Antibiotic prophylaxis
Surgery
Tobramycin

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title = "Oral tobramycin prophylaxis prior to colorectal surgery is not associated with systemic uptake",

abstract = "Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.",

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AU - Mulder, T.

AU - Kluytmans-Van Den Bergh, M. F.Q.

AU - Crolla, Rogier M P H

AU - Ermens, A A M

AU - Romme, J

AU - Van'T Veer, Nils E.

AU - Kluytmans, J. A.J.W.

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N2 - Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.

AB - Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.

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KW - Surgery

KW - Tobramycin

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DO - 10.1128/AAC.01723-17

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JF - Antimicrobial Agents and Chemotherapy

IS - 1

M1 - e01723

ER -

Oral tobramycin prophylaxis prior to colorectal surgery is not associated with systemic uptake

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Keywords

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