Abstract
OBJECTIVE: To determine factors associated with local recurrence (LR) of oral squamous cell carcinoma involving the maxillae (MSCC) and overall survival (OS) after salvage treatment.
SUBJECTS AND METHODS: Retrospective study of MSCC operated between 2000 and 2015. Kaplan-Meier survival and Cox regression were used for analysis of MSCC-associated clinical and histopathological factors.
RESULTS: Ninety-five patients were included. LR occurred in 24% of patients. Vascular invasion significantly increased the risk of LR (hazard ratio 4.595, P = .003). Local salvage surgery, in the area of the original tumor, significantly prolonged OS, compared to palliative treatment (P = .001) and extensive salvage surgery (P = .013). Extensive salvage surgery, requiring resection of adjacent facial structures, did not prolong OS compared to palliative treatment (P = .186).
CONCLUSIONS: MSCC with vascular invasion has higher risk of LR. Salvage surgery may prolong OS in small recurrences but might have dubious value for larger recurrences infiltrating adjacent facial structures.
Original language | English |
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Pages (from-to) | 1821-1828 |
Number of pages | 8 |
Journal | Head & neck |
Volume | 42 |
Issue number | 8 |
Early online date | 26 Feb 2020 |
DOIs | |
Publication status | Published - Aug 2020 |
Keywords
- 5-year local control
- malignancy
- maxillary cancer
- maxillectomy
- salvage treatment
- squamous cell carcinoma