Oral pulsed high-dose dexamethasone for myositis

M.F.G. van der Meulen; J.E. Hoogendijk; J.H.J. Wokke; M. de Visser

Oral pulsed high-dose dexamethasone for myositis

M.F.G. van der Meulen
, J.E. Hoogendijk
, J.H.J. Wokke
, M. de Visser

Neurology & Neurosurgery

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without medication. Pulsed high-dose dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.

Original language	English
Pages (from-to)	102-105
Number of pages	4
Journal	Journal of Neurology
Volume	247
Issue number	2
Publication status	Published - Feb 2000

Keywords

Administration, Oral
Adult
Dexamethasone
Female
Humans
Male
Middle Aged
Myositis
Pulse Therapy, Drug
Journal Article

Cite this

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title = "Oral pulsed high-dose dexamethasone for myositis",

abstract = "To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without medication. Pulsed high-dose dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.",

keywords = "Administration, Oral, Adult, Dexamethasone, Female, Humans, Male, Middle Aged, Myositis, Pulse Therapy, Drug, Journal Article",

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T1 - Oral pulsed high-dose dexamethasone for myositis

AU - van der Meulen, M.F.G.

AU - Hoogendijk, J.E.

AU - Wokke, J.H.J.

AU - de Visser, M.

PY - 2000/2

Y1 - 2000/2

N2 - To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without medication. Pulsed high-dose dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.

AB - To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without medication. Pulsed high-dose dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.

KW - Administration, Oral

KW - Adult

KW - Dexamethasone

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Myositis

KW - Pulse Therapy, Drug

KW - Journal Article

M3 - Article

C2 - 10751111

SN - 0340-5354

VL - 247

SP - 102

EP - 105

JO - Journal of Neurology

JF - Journal of Neurology

IS - 2

ER -

Oral pulsed high-dose dexamethasone for myositis

Abstract

Keywords

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