TY - JOUR
T1 - Optimal High-Dose-Rate Brachytherapy Fractionation Scheme After Keloid Excision
T2 - A Retrospective Multicenter Comparison of Recurrence Rates and Complications
AU - Bijlard, Eveline
AU - Verduijn, Gerda M.
AU - Harmeling, J. X.
AU - Dehnad, Homan
AU - Niessen, Frank B.
AU - Meijer, Otto W.M.
AU - Mureau, Marc A.M.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Purpose: To determine the optimal brachytherapy dose and fractionation scheme for keloid treatment. Methods and Materials: Patient cohorts from 3 centers treated with keloid excision followed by 2 × 9 Gy, 3 × 6 Gy, or 2 × 6 Gy high-dose-rate brachytherapy were retrospectively compared regarding recurrence (after at least 12 months' follow-up) and complications (after at least 1 month's follow-up), using logistic regression analyses. Results: A total of 238 keloids were treated. An overall full recurrence rate of 8.3% was found. After correction for confounders (sex, skin color, keloid location, keloid duration) no statistically significant differences in recurrence rates could be discerned between fractionation schemes. There were 12.8% major and 45.6% minor complication rates. Lower radiation dose resulted in significantly fewer complications (odds ratio 0.35, P=.015). Conclusions: After excision of resistant keloids, high-dose-rate brachytherapy with a biological equivalent dose of approximately 20 Gy is recommended, on the basis of low recurrence and complication rates.
AB - Purpose: To determine the optimal brachytherapy dose and fractionation scheme for keloid treatment. Methods and Materials: Patient cohorts from 3 centers treated with keloid excision followed by 2 × 9 Gy, 3 × 6 Gy, or 2 × 6 Gy high-dose-rate brachytherapy were retrospectively compared regarding recurrence (after at least 12 months' follow-up) and complications (after at least 1 month's follow-up), using logistic regression analyses. Results: A total of 238 keloids were treated. An overall full recurrence rate of 8.3% was found. After correction for confounders (sex, skin color, keloid location, keloid duration) no statistically significant differences in recurrence rates could be discerned between fractionation schemes. There were 12.8% major and 45.6% minor complication rates. Lower radiation dose resulted in significantly fewer complications (odds ratio 0.35, P=.015). Conclusions: After excision of resistant keloids, high-dose-rate brachytherapy with a biological equivalent dose of approximately 20 Gy is recommended, on the basis of low recurrence and complication rates.
UR - http://www.scopus.com/inward/record.url?scp=85039035775&partnerID=8YFLogxK
U2 - 10.1016/j.ijrobp.2017.10.044
DO - 10.1016/j.ijrobp.2017.10.044
M3 - Article
C2 - 29249529
AN - SCOPUS:85039035775
SN - 0360-3016
VL - 100
SP - 679
EP - 686
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 3
ER -