One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study

Gennaro Giustino; Usman Baber; Ioannis Mastoris; Georgios J Vlachojannis; Jennifer Yu; Paul S Teirstein; William E Downey; Wayne B Batchelor; Peter J Casterella; Eugenia Nikolsky; S Chiu Wong; Kleanthis N Theodoropoulos; George D Dangas; Roxana Mehran

doi:10.1002/ccd.26106

One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study

Gennaro Giustino, Usman Baber, Ioannis Mastoris, Georgios J Vlachojannis, Jennifer Yu, Paul S Teirstein, William E Downey, Wayne B Batchelor, Peter J Casterella, Eugenia Nikolsky, S Chiu Wong, Kleanthis N Theodoropoulos, George D Dangas, Roxana Mehran

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Long-term clinical outcomes after exposure to non-ionic iso-osmolar contrast medium (IOCM) or ionic low-osmolar CM (LOCM) in patients with chronic kidney disease (CKD) undergoing coronary angiography are unclear.

METHODS: The ICON trial was a prospective, double-blinded, multicentre study that randomly assigned 146 patients with CKD undergoing coronary angiography with or without percutaneous coronary intervention to the non-ionic IOCM Iodixanol or the ionic LOCM Ioxaglate. We report the 1-year clinical outcomes.

RESULTS: After randomization, baseline and procedural characteristics were well-matched between the two groups. At 1 year, three deaths (4.1%) occurred in the ioxaglate and nine deaths in the iodixanol group (13.6%, P = 0.07). The cardiac death rate at 1 year was 2.7% in the ioxaglate group and 9.1% in the iodixanol group (P = 0.07). There were no significant differences in the rates of myocardial infarction (1.4% vs. 1.5%; P = 1.00) and repeated revascularization (6.8% vs. 9.1%; P = 0.75).

CONCLUSIONS: The use of ionic LOCM ioxaglate was associated with a numerically lower mortality at 1 year as compared to iodixanol in patients who underwent cardiac catheterization. Future studies evaluating long-term safety following exposure to different types of CM are warranted.

Original language	English
Pages (from-to)	703-9
Number of pages	7
Journal	Catheterization and Cardiovascular Interventions
Volume	87
Issue number	4
DOIs	https://doi.org/10.1002/ccd.26106
Publication status	Published - Mar 2016
Externally published	Yes

Keywords

Acute Kidney Injury/chemically induced
Aged
Aged, 80 and over
Angioplasty, Balloon, Coronary/adverse effects
Contrast Media/adverse effects
Coronary Angiography/adverse effects
Coronary Artery Disease/diagnostic imaging
Disease Progression
Double-Blind Method
Female
Humans
Ioxaglic Acid/adverse effects
Kidney Failure, Chronic/complications
Male
Middle Aged
Myocardial Infarction/etiology
Predictive Value of Tests
Prospective Studies
Risk Factors
Time Factors
Treatment Outcome
Triiodobenzoic Acids/adverse effects

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10.1002/ccd.26106

Cite this

Giustino, G., Baber, U., Mastoris, I., Vlachojannis, G. J., Yu, J., Teirstein, P. S., Downey, W. E., Batchelor, W. B., Casterella, P. J., Nikolsky, E., Wong, S. C., Theodoropoulos, K. N., Dangas, G. D., & Mehran, R. (2016). One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study. Catheterization and Cardiovascular Interventions, 87(4), 703-9. https://doi.org/10.1002/ccd.26106

@article{884c5d06d0f94dd3b3de4517d734c570,

title = "One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study",

abstract = "BACKGROUND: Long-term clinical outcomes after exposure to non-ionic iso-osmolar contrast medium (IOCM) or ionic low-osmolar CM (LOCM) in patients with chronic kidney disease (CKD) undergoing coronary angiography are unclear.METHODS: The ICON trial was a prospective, double-blinded, multicentre study that randomly assigned 146 patients with CKD undergoing coronary angiography with or without percutaneous coronary intervention to the non-ionic IOCM Iodixanol or the ionic LOCM Ioxaglate. We report the 1-year clinical outcomes.RESULTS: After randomization, baseline and procedural characteristics were well-matched between the two groups. At 1 year, three deaths (4.1%) occurred in the ioxaglate and nine deaths in the iodixanol group (13.6%, P = 0.07). The cardiac death rate at 1 year was 2.7% in the ioxaglate group and 9.1% in the iodixanol group (P = 0.07). There were no significant differences in the rates of myocardial infarction (1.4% vs. 1.5%; P = 1.00) and repeated revascularization (6.8% vs. 9.1%; P = 0.75).CONCLUSIONS: The use of ionic LOCM ioxaglate was associated with a numerically lower mortality at 1 year as compared to iodixanol in patients who underwent cardiac catheterization. Future studies evaluating long-term safety following exposure to different types of CM are warranted.",

keywords = "Acute Kidney Injury/chemically induced, Aged, Aged, 80 and over, Angioplasty, Balloon, Coronary/adverse effects, Contrast Media/adverse effects, Coronary Angiography/adverse effects, Coronary Artery Disease/diagnostic imaging, Disease Progression, Double-Blind Method, Female, Humans, Ioxaglic Acid/adverse effects, Kidney Failure, Chronic/complications, Male, Middle Aged, Myocardial Infarction/etiology, Predictive Value of Tests, Prospective Studies, Risk Factors, Time Factors, Treatment Outcome, Triiodobenzoic Acids/adverse effects",

author = "Gennaro Giustino and Usman Baber and Ioannis Mastoris and Vlachojannis, {Georgios J} and Jennifer Yu and Teirstein, {Paul S} and Downey, {William E} and Batchelor, {Wayne B} and Casterella, {Peter J} and Eugenia Nikolsky and Wong, {S Chiu} and Theodoropoulos, {Kleanthis N} and Dangas, {George D} and Roxana Mehran",

note = "{\textcopyright} 2015 Wiley Periodicals, Inc.",

year = "2016",

month = mar,

doi = "10.1002/ccd.26106",

language = "English",

volume = "87",

pages = "703--9",

journal = "Catheterization and Cardiovascular Interventions",

issn = "1522-1946",

publisher = "John Wiley & Sons Inc.",

number = "4",

}

Giustino, G, Baber, U, Mastoris, I, Vlachojannis, GJ, Yu, J, Teirstein, PS, Downey, WE, Batchelor, WB, Casterella, PJ, Nikolsky, E, Wong, SC, Theodoropoulos, KN, Dangas, GD & Mehran, R 2016, 'One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study', Catheterization and Cardiovascular Interventions, vol. 87, no. 4, pp. 703-9. https://doi.org/10.1002/ccd.26106

One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study. / Giustino, Gennaro; Baber, Usman; Mastoris, Ioannis et al.
In: Catheterization and Cardiovascular Interventions, Vol. 87, No. 4, 03.2016, p. 703-9.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study

AU - Giustino, Gennaro

AU - Baber, Usman

AU - Mastoris, Ioannis

AU - Vlachojannis, Georgios J

AU - Yu, Jennifer

AU - Teirstein, Paul S

AU - Downey, William E

AU - Batchelor, Wayne B

AU - Casterella, Peter J

AU - Nikolsky, Eugenia

AU - Wong, S Chiu

AU - Theodoropoulos, Kleanthis N

AU - Dangas, George D

AU - Mehran, Roxana

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND: Long-term clinical outcomes after exposure to non-ionic iso-osmolar contrast medium (IOCM) or ionic low-osmolar CM (LOCM) in patients with chronic kidney disease (CKD) undergoing coronary angiography are unclear.METHODS: The ICON trial was a prospective, double-blinded, multicentre study that randomly assigned 146 patients with CKD undergoing coronary angiography with or without percutaneous coronary intervention to the non-ionic IOCM Iodixanol or the ionic LOCM Ioxaglate. We report the 1-year clinical outcomes.RESULTS: After randomization, baseline and procedural characteristics were well-matched between the two groups. At 1 year, three deaths (4.1%) occurred in the ioxaglate and nine deaths in the iodixanol group (13.6%, P = 0.07). The cardiac death rate at 1 year was 2.7% in the ioxaglate group and 9.1% in the iodixanol group (P = 0.07). There were no significant differences in the rates of myocardial infarction (1.4% vs. 1.5%; P = 1.00) and repeated revascularization (6.8% vs. 9.1%; P = 0.75).CONCLUSIONS: The use of ionic LOCM ioxaglate was associated with a numerically lower mortality at 1 year as compared to iodixanol in patients who underwent cardiac catheterization. Future studies evaluating long-term safety following exposure to different types of CM are warranted.

AB - BACKGROUND: Long-term clinical outcomes after exposure to non-ionic iso-osmolar contrast medium (IOCM) or ionic low-osmolar CM (LOCM) in patients with chronic kidney disease (CKD) undergoing coronary angiography are unclear.METHODS: The ICON trial was a prospective, double-blinded, multicentre study that randomly assigned 146 patients with CKD undergoing coronary angiography with or without percutaneous coronary intervention to the non-ionic IOCM Iodixanol or the ionic LOCM Ioxaglate. We report the 1-year clinical outcomes.RESULTS: After randomization, baseline and procedural characteristics were well-matched between the two groups. At 1 year, three deaths (4.1%) occurred in the ioxaglate and nine deaths in the iodixanol group (13.6%, P = 0.07). The cardiac death rate at 1 year was 2.7% in the ioxaglate group and 9.1% in the iodixanol group (P = 0.07). There were no significant differences in the rates of myocardial infarction (1.4% vs. 1.5%; P = 1.00) and repeated revascularization (6.8% vs. 9.1%; P = 0.75).CONCLUSIONS: The use of ionic LOCM ioxaglate was associated with a numerically lower mortality at 1 year as compared to iodixanol in patients who underwent cardiac catheterization. Future studies evaluating long-term safety following exposure to different types of CM are warranted.

KW - Acute Kidney Injury/chemically induced

KW - Aged

KW - Aged, 80 and over

KW - Angioplasty, Balloon, Coronary/adverse effects

KW - Contrast Media/adverse effects

KW - Coronary Angiography/adverse effects

KW - Coronary Artery Disease/diagnostic imaging

KW - Disease Progression

KW - Double-Blind Method

KW - Female

KW - Humans

KW - Ioxaglic Acid/adverse effects

KW - Kidney Failure, Chronic/complications

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/etiology

KW - Predictive Value of Tests

KW - Prospective Studies

KW - Risk Factors

KW - Time Factors

KW - Treatment Outcome

KW - Triiodobenzoic Acids/adverse effects

U2 - 10.1002/ccd.26106

DO - 10.1002/ccd.26106

M3 - Article

C2 - 26481591

SN - 1522-1946

VL - 87

SP - 703

EP - 709

JO - Catheterization and Cardiovascular Interventions

JF - Catheterization and Cardiovascular Interventions

IS - 4

ER -

One-year results of the ICON (Ionic versus non-ionic Contrast to Obviate worsening Nephropathy after angioplasty in chronic renal failure patients) Study

Abstract

Keywords

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