Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani; Yoshiyuki Tsukamoto; Hans Clevers

doi:10.1083/jcb.201704014

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Tomohiro Mizutani, Yoshiyuki Tsukamoto, Hans Clevers^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Abstract

Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

Original language	English
Pages (from-to)	1505-1507
Number of pages	3
Journal	Journal of Cell Biology
Volume	216
Issue number	6
DOIs	https://doi.org/10.1083/jcb.201704014
Publication status	Published - 1 Jun 2017

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title = "Oncogene-inducible organoids as a miniature platform to assess cancer characteristics",

abstract = "Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.",

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AU - Mizutani, Tomohiro

AU - Tsukamoto, Yoshiyuki

AU - Clevers, Hans

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AB - Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.

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U2 - 10.1083/jcb.201704014

DO - 10.1083/jcb.201704014

M3 - Comment/Letter to the editor

C2 - 28512141

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Oncogene-inducible organoids as a miniature platform to assess cancer characteristics

Abstract

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