TY - JOUR
T1 - Oncogene-inducible organoids as a miniature platform to assess cancer characteristics
AU - Mizutani, Tomohiro
AU - Tsukamoto, Yoshiyuki
AU - Clevers, Hans
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.
AB - Direct effects of oncogenic proteins or inhibitor treatments on signaling pathways are difficult to assess in transgenic mice. In this issue, Riemer et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610058) demonstrate that oncogene-inducible organoids offer the experimental versatility of two-dimensional cell lines, while closely representing the in vivo situation.
UR - http://www.scopus.com/inward/record.url?scp=85021783817&partnerID=8YFLogxK
U2 - 10.1083/jcb.201704014
DO - 10.1083/jcb.201704014
M3 - Comment/Letter to the editor
C2 - 28512141
AN - SCOPUS:85021783817
SN - 0021-9525
VL - 216
SP - 1505
EP - 1507
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 6
ER -