On Naivety of T Cells in Inflammatory Bowel Disease: A Review

Carolijn Smids; Carmen S. Horjus Talabur Horje; Peter J. Wahab; Marcel J. M. Groenen; Sabine Middendorp; Ellen G. van Lochem

doi:10.1097/MIB.0000000000000221

On Naivety of T Cells in Inflammatory Bowel Disease: A Review

Carolijn Smids^*, Carmen S. Horjus Talabur Horje, Peter J. Wahab, Marcel J. M. Groenen, Sabine Middendorp, Ellen G. van Lochem

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract

Little is known about different phases of T-cell maturation in gut mucosa. Based on current knowledge about the migratory pathways of naive and memory T cells, it is believed that access to peripheral, nonlymphoid tissues is restricted to memory T cells. Surprisingly, there is increasing evidence of high numbers of naive T cells in the chronically inflamed gut tissue of patients with inflammatory bowel disease. This could partially be explained by new formation of ectopic lymphoid organs. Ongoing recruitment of naive T cells at inflammatory sites might play a role in the immunopathogenesis of inflammatory bowel disease.

Original language	English
Pages (from-to)	167-172
Number of pages	6
Journal	Inflammatory bowel diseases
Volume	21
Issue number	1
DOIs	https://doi.org/10.1097/MIB.0000000000000221
Publication status	Published - Jan 2015

Keywords

Crohn's disease
ulcerative colitis
T-cell subsets
naive T cells
tertiary lymphoid organ

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title = "On Naivety of T Cells in Inflammatory Bowel Disease: A Review",

abstract = "Little is known about different phases of T-cell maturation in gut mucosa. Based on current knowledge about the migratory pathways of naive and memory T cells, it is believed that access to peripheral, nonlymphoid tissues is restricted to memory T cells. Surprisingly, there is increasing evidence of high numbers of naive T cells in the chronically inflamed gut tissue of patients with inflammatory bowel disease. This could partially be explained by new formation of ectopic lymphoid organs. Ongoing recruitment of naive T cells at inflammatory sites might play a role in the immunopathogenesis of inflammatory bowel disease.",

keywords = "Crohn's disease, ulcerative colitis, T-cell subsets, naive T cells, tertiary lymphoid organ",

author = "Carolijn Smids and Horje, {Carmen S. Horjus Talabur} and Wahab, {Peter J.} and Groenen, {Marcel J. M.} and Sabine Middendorp and {van Lochem}, {Ellen G.}",

year = "2015",

month = jan,

doi = "10.1097/MIB.0000000000000221",

language = "English",

volume = "21",

pages = "167--172",

journal = "Inflammatory bowel diseases",

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AU - Smids, Carolijn

AU - Horje, Carmen S. Horjus Talabur

AU - Wahab, Peter J.

AU - Groenen, Marcel J. M.

AU - Middendorp, Sabine

AU - van Lochem, Ellen G.

PY - 2015/1

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AB - Little is known about different phases of T-cell maturation in gut mucosa. Based on current knowledge about the migratory pathways of naive and memory T cells, it is believed that access to peripheral, nonlymphoid tissues is restricted to memory T cells. Surprisingly, there is increasing evidence of high numbers of naive T cells in the chronically inflamed gut tissue of patients with inflammatory bowel disease. This could partially be explained by new formation of ectopic lymphoid organs. Ongoing recruitment of naive T cells at inflammatory sites might play a role in the immunopathogenesis of inflammatory bowel disease.

KW - Crohn's disease

KW - ulcerative colitis

KW - T-cell subsets

KW - naive T cells

KW - tertiary lymphoid organ

U2 - 10.1097/MIB.0000000000000221

DO - 10.1097/MIB.0000000000000221

M3 - Literature review

C2 - 25268637

SN - 1078-0998

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SP - 167

EP - 172

JO - Inflammatory bowel diseases

JF - Inflammatory bowel diseases

IS - 1

ER -

On Naivety of T Cells in Inflammatory Bowel Disease: A Review

Abstract

Keywords

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