Oligodendrocyte precursors guide interneuron migration by unidirectional contact repulsion

Fanny Lepiemme; Julie Stoufflet; Míriam Javier-Torrent; Gabriel Mazzucchelli; Carla G Silva; Laurent Nguyen

doi:10.1126/science.abn6204

Oligodendrocyte precursors guide interneuron migration by unidirectional contact repulsion

Fanny Lepiemme, Julie Stoufflet, Míriam Javier-Torrent, Gabriel Mazzucchelli, Carla G Silva, Laurent Nguyen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.

Original language	English
Article number	abn6204
Journal	Science
Volume	376
Issue number	6595
DOIs	https://doi.org/10.1126/science.abn6204
Publication status	Published - 20 May 2022
Externally published	Yes

Keywords

Animals
Cell Movement/genetics
Cerebral Cortex/cytology
Chemokine CXCL12/metabolism
Interneurons/physiology
Mice
Models, Genetic
Neurogenesis/genetics
Oligodendrocyte Precursor Cells/cytology

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10.1126/science.abn6204

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title = "Oligodendrocyte precursors guide interneuron migration by unidirectional contact repulsion",

abstract = "In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.",

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month = may,

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doi = "10.1126/science.abn6204",

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AU - Lepiemme, Fanny

AU - Stoufflet, Julie

AU - Javier-Torrent, Míriam

AU - Mazzucchelli, Gabriel

AU - Silva, Carla G

AU - Nguyen, Laurent

PY - 2022/5/20

Y1 - 2022/5/20

N2 - In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.

AB - In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.

KW - Animals

KW - Cell Movement/genetics

KW - Cerebral Cortex/cytology

KW - Chemokine CXCL12/metabolism

KW - Interneurons/physiology

KW - Mice

KW - Models, Genetic

KW - Neurogenesis/genetics

KW - Oligodendrocyte Precursor Cells/cytology

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VL - 376

JO - Science

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IS - 6595

M1 - abn6204

ER -

Oligodendrocyte precursors guide interneuron migration by unidirectional contact repulsion

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Keywords

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