Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population

Eduardo Loeb; Jan Paul Zock; Marc Miravitlles; Esther Rodríguez; Hans Kromhout; Roel Vermeulen; Juan José Soler-Cataluña; Joan B. Soriano; Francisco García-Río; Pilar de Lucas; Inmaculada Alfageme; Ciro Casanova; José Rodríguez González-Moro; Julio Ancochea; Borja G. Cosío; Jaume Ferrer Sancho

doi:10.3390/toxics12100689

Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population

Eduardo Loeb, Jan Paul Zock, Marc Miravitlles, Esther Rodríguez, Hans Kromhout, Roel Vermeulen, Juan José Soler-Cataluña, Joan B. Soriano, Francisco García-Río, Pilar de Lucas, Inmaculada Alfageme, Ciro Casanova, José Rodríguez González-Moro, Julio Ancochea, Borja G. Cosío, Jaume Ferrer Sancho^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19–4.22), biological dust (OR 3.01 95% CI 1.22–7.45), gases/fumes (OR 2.49 95% CI 1.20–5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21–16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42–24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16–15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population.

Original language	English
Article number	689
Journal	Toxics
Volume	12
Issue number	10
DOIs	https://doi.org/10.3390/toxics12100689
Publication status	Published - Oct 2024

Keywords

chronic obstructive pulmonary disease
computed tomography
COPD
emphysema
JEM
job exposure matrix
occupational exposures

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10.3390/toxics12100689Licence: CC BY

toxics-12-00689Final published version, 292 KBLicence: CC BY

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Loeb, E., Zock, J. P., Miravitlles, M., Rodríguez, E., Kromhout, H., Vermeulen, R., Soler-Cataluña, J. J., Soriano, J. B., García-Río, F., de Lucas, P., Alfageme, I., Casanova, C., González-Moro, J. R., Ancochea, J., Cosío, B. G., & Ferrer Sancho, J. (2024). Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population. Toxics, 12(10), Article 689. https://doi.org/10.3390/toxics12100689

@article{113442b4a50d453da85479dbc8a023aa,

title = "Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population",

abstract = "Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19–4.22), biological dust (OR 3.01 95% CI 1.22–7.45), gases/fumes (OR 2.49 95% CI 1.20–5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21–16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42–24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16–15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population.",

keywords = "chronic obstructive pulmonary disease, computed tomography, COPD, emphysema, JEM, job exposure matrix, occupational exposures",

author = "Eduardo Loeb and Zock, {Jan Paul} and Marc Miravitlles and Esther Rodr{\'i}guez and Hans Kromhout and Roel Vermeulen and Soler-Catalu{\~n}a, {Juan Jos{\'e}} and Soriano, {Joan B.} and Francisco Garc{\'i}a-R{\'i}o and {de Lucas}, Pilar and Inmaculada Alfageme and Ciro Casanova and Gonz{\'a}lez-Moro, {Jos{\'e} Rodr{\'i}guez} and Julio Ancochea and Cos{\'i}o, {Borja G.} and {Ferrer Sancho}, Jaume",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = oct,

doi = "10.3390/toxics12100689",

language = "English",

volume = "12",

journal = "Toxics",

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Loeb, E, Zock, JP, Miravitlles, M, Rodríguez, E, Kromhout, H, Vermeulen, R, Soler-Cataluña, JJ, Soriano, JB, García-Río, F, de Lucas, P, Alfageme, I, Casanova, C, González-Moro, JR, Ancochea, J, Cosío, BG & Ferrer Sancho, J 2024, 'Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population', Toxics, vol. 12, no. 10, 689. https://doi.org/10.3390/toxics12100689

TY - JOUR

T1 - Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population

AU - Loeb, Eduardo

AU - Zock, Jan Paul

AU - Miravitlles, Marc

AU - Rodríguez, Esther

AU - Kromhout, Hans

AU - Vermeulen, Roel

AU - Soler-Cataluña, Juan José

AU - Soriano, Joan B.

AU - García-Río, Francisco

AU - de Lucas, Pilar

AU - Alfageme, Inmaculada

AU - Casanova, Ciro

AU - González-Moro, José Rodríguez

AU - Ancochea, Julio

AU - Cosío, Borja G.

AU - Ferrer Sancho, Jaume

PY - 2024/10

Y1 - 2024/10

N2 - Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19–4.22), biological dust (OR 3.01 95% CI 1.22–7.45), gases/fumes (OR 2.49 95% CI 1.20–5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21–16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42–24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16–15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population.

AB - Self-reported occupational exposure was previously associated with COPD in the Spanish population. This study aimed to analyse the relationship between occupational exposure to various chemical and biological agents, COPD, emphysema, and the bronchial wall area, which was determined by lung computed tomography (CT) in 226 individuals with COPD and 300 individuals without COPD. Lifetime occupational exposures were assessed using the ALOHA(+) job exposure matrix, and CT and spirometry were also performed. COPD was associated with high exposure to vapours, gases, dust and fumes (VGDF) (OR 2.25 95% CI 1.19–4.22), biological dust (OR 3.01 95% CI 1.22–7.45), gases/fumes (OR 2.49 95% CI 1.20–5.17) and with exposure to various types of solvents. High exposure to gases/fumes, chlorinated solvents and metals (coefficient 8.65 95% CI 1.21–16.09, 11.91 95%CI 0.46- 23.36, 14.45 95% CI 4.42–24.49, respectively) and low exposure to aromatic solvents (coefficient 8.43 95% CI 1.16–15.70) were associated with a low 15th percentile of lung density indicating emphysema. We conclude that occupational exposure to several specific agents is associated with COPD and emphysema in the Spanish population.

KW - chronic obstructive pulmonary disease

KW - computed tomography

KW - COPD

KW - emphysema

KW - JEM

KW - job exposure matrix

KW - occupational exposures

UR - http://www.scopus.com/inward/record.url?scp=85207673156&partnerID=8YFLogxK

U2 - 10.3390/toxics12100689

DO - 10.3390/toxics12100689

M3 - Article

AN - SCOPUS:85207673156

SN - 2305-6304

VL - 12

JO - Toxics

JF - Toxics

IS - 10

M1 - 689

ER -

Occupational Exposures, Chronic Obstructive Pulmonary Disease and Tomographic Findings in the Spanish Population

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