Occupational Exposure of Healthcare Workers during Drug Reconstitution and Handling Tasks: A multicenter assessment at Dutch Hospital Wards

Objective This study evaluated healthcare workers' occupational exposure to inhaled drugs during drug reconstitution and handling tasks, focusing on compliance with occupational exposure limits (OELs). Methods Ten nurses and pharmacy technicians were monitored during an 8-hour shift to measure inhalable particle concentrations using a portable sampling device. Results Inhalable particle concentrations ranged from <15 to 381 μg/m3 (arithmetic mean 83 μg/m3). Exposure to drugs in hazardous drug classes (HDCs) 1, 2, and 3 complied with OELs, while exposure to drugs in HDCs 4 and 5 exceeded OELs, highlighting the need for enhanced protective measures. Conclusions No additional precautions are needed for drugs in HDCs 1, 2, and 3, but dust exhaust or biosafety cabinets are recommended for handling drugs in HDCs 4 and 5.