Nuclear medicine therapy of liver metastasis with radiolabelled spheres

Radioembolization, also known as selective internal radiation therapy (SIRT) or trans-arterial radioembolization (TARE), is a liver-directed therapy for hepatic malignancies. Tumors are irradiated internally through administration of radioactive microspheres into the hepatic arterial vasculature via a microcatheter. Radioembolization is mostly applied as a stand-alone treatment in salvage patients with liver-dominant disease, but has shown potential in earlier lines of therapy. The efficacy and safety of radioembolization have been established in patients with primary liver tumors such as hepatocellular carcinoma, intrahepatic cholangiocarcinoma, as well as in metastatic liver tumors, like colorectal cancer, breast cancer, neuroendocrine tumors (NET) and uveal melanoma.