Notch-Rho-cGMP interaction: Common point of convergence in microvascular aging-related disease

Anton J.M. Roks*, Caroline Cheng, Catherine M. Shanahan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3-Rho kinase-cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.

Original languageEnglish
Pages (from-to)1209-1212
Number of pages4
JournalClinical Science
Volume135
Issue number10
DOIs
Publication statusPublished - May 2021

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