Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation

Yvonne Pannekoek; A. van der Ende; Paul P. Eijk; J. van Marle; M A de Witte; Tjaco J M Ossewaarde; Adriaan J. C. van den Brule; Servaas A Morré; J. Dankert

doi:10.1128/IAI.69.7.4654-4656.2001

Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation

Yvonne Pannekoek, A. van der Ende, Paul P. Eijk, J. van Marle, M A de Witte, Tjaco J M Ossewaarde, Adriaan J. C. van den Brule, Servaas A Morré, J. Dankert

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates were sequenced. Four major sequence types were identified. Seven isolates (28%) had the I47T mutation. Isolates representing the four sequence types expressed IncA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype.

Original language	English
Pages (from-to)	4654-6
Number of pages	3
Journal	Infection and Immunity
Volume	69
Issue number	7
DOIs	https://doi.org/10.1128/IAI.69.7.4654-4656.2001
Publication status	Published - Jul 2001

Keywords

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Chlamydia trachomatis
DNA, Bacterial
Gene Expression
Inclusion Bodies
Molecular Sequence Data
Mutation
Phosphoproteins
Journal Article

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10.1128/IAI.69.7.4654-4656.2001

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@article{788dd00caebb4e8d8272e3dc2aba6c84,

title = "Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation",

abstract = "To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates were sequenced. Four major sequence types were identified. Seven isolates (28%) had the I47T mutation. Isolates representing the four sequence types expressed IncA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype.",

keywords = "Amino Acid Sequence, Bacterial Proteins, Base Sequence, Chlamydia trachomatis, DNA, Bacterial, Gene Expression, Inclusion Bodies, Molecular Sequence Data, Mutation, Phosphoproteins, Journal Article",

author = "Yvonne Pannekoek and {van der Ende}, A. and Eijk, {Paul P.} and {van Marle}, J. and {de Witte}, {M A} and Ossewaarde, {Tjaco J M} and {van den Brule}, {Adriaan J. C.} and Morr{\'e}, {Servaas A} and J. Dankert",

year = "2001",

month = jul,

doi = "10.1128/IAI.69.7.4654-4656.2001",

language = "English",

volume = "69",

pages = "4654--6",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "7",

}

TY - JOUR

T1 - Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation

AU - Pannekoek, Yvonne

AU - van der Ende, A.

AU - Eijk, Paul P.

AU - van Marle, J.

AU - de Witte, M A

AU - Ossewaarde, Tjaco J M

AU - van den Brule, Adriaan J. C.

AU - Morré, Servaas A

AU - Dankert, J.

PY - 2001/7

Y1 - 2001/7

N2 - To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates were sequenced. Four major sequence types were identified. Seven isolates (28%) had the I47T mutation. Isolates representing the four sequence types expressed IncA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype.

AB - To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates were sequenced. Four major sequence types were identified. Seven isolates (28%) had the I47T mutation. Isolates representing the four sequence types expressed IncA in the membrane of one large single inclusion. In conclusion, the incA I47T mutation is not associated with the nonfusogenic phenotype.

KW - Amino Acid Sequence

KW - Bacterial Proteins

KW - Base Sequence

KW - Chlamydia trachomatis

KW - DNA, Bacterial

KW - Gene Expression

KW - Inclusion Bodies

KW - Molecular Sequence Data

KW - Mutation

KW - Phosphoproteins

KW - Journal Article

U2 - 10.1128/IAI.69.7.4654-4656.2001

DO - 10.1128/IAI.69.7.4654-4656.2001

M3 - Article

C2 - 11402010

SN - 0019-9567

VL - 69

SP - 4654

EP - 4656

JO - Infection and Immunity

JF - Infection and Immunity

IS - 7

ER -

Normal IncA expression and fusogenicity of inclusions in Chlamydia trachomatis isolates with the incA I47T mutation

Abstract

Keywords

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