Normal imaging findings after aortic valve implantation on 
            18F-Fluorodeoxyglucose positron emission tomography with computed tomography

Ali R Wahadat; Wilco Tanis; Asbjørn M Scholtens; Margreet Bekker; Laura H Graven; Laurens E Swart; Annemarie M den Harder; Marnix G E H Lam; Linda M de Heer; Jolien W Roos-Hesselink; Ricardo P J Budde

doi:10.1007/s12350-019-02025-y

Normal imaging findings after aortic valve implantation on ¹⁸F-Fluorodeoxyglucose positron emission tomography with computed tomography

Ali R Wahadat
, Wilco Tanis
, Asbjørn M Scholtens
, Margreet Bekker
, Laura H Graven
, Laurens E Swart
, Annemarie M den Harder
, Marnix G E H Lam
, Linda M de Heer
, Jolien W Roos-Hesselink
, Ricardo P J Budde

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: To determine the normal perivalvular 18F-Fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography (PET) with computed tomography (CT) within one year after aortic prosthetic heart valve (PHV) implantation.

METHODS: Patients with uncomplicated aortic PHV implantation were prospectively included and underwent 18F-FDG PET/CT at either 5 (± 1) weeks (group 1), 12 (± 2) weeks (group 2) or 52 (± 8) weeks (group 3) after implantation. 18F-FDG uptake around the PHV was scored qualitatively (none/low/intermediate/high) and quantitatively by measuring the maximum Standardized Uptake Value (SUVmax) and target to background ratio (SUVratio).

RESULTS: In total, 37 patients (group 1: n = 12, group 2: n = 12, group 3: n = 13) (mean age 66 ± 8 years) were prospectively included. Perivalvular 18F-FDG uptake was low (8/12 (67%)) and intermediate (4/12 (33%)) in group 1, low (7/12 (58%)) and intermediate (5/12 (42%)) in group 2, and low (8/13 (62%)) and intermediate (5/13 (38%)) in group 3 (P = 0.91). SUVmax was 4.1 ± 0.7, 4.6 ± 0.9 and 3.8 ± 0.7 (mean ± SD, P = 0.08), and SUVratio was 2.0 [1.9 to 2.2], 2.0 [1.8 to 2.6], and 1.9 [1.7 to 2.0] (median [IQR], P = 0.81) for groups 1, 2, and 3, respectively.

CONCLUSION: Non-infected aortic PHV have similar low to intermediate perivalvular 18F-FDG uptake with similar SUVmax and SUVratio at 5, 12, and 52 weeks after implantation.

Original language	English
Pages (from-to)	2258-2268
Number of pages	11
Journal	Journal of Nuclear Cardiology
Volume	28
Issue number	5
Early online date	23 Jan 2020
DOIs	https://doi.org/10.1007/s12350-019-02025-y
Publication status	Published - Oct 2021

Keywords

Image interpretation
Infection
Inflammation
PET
Valvular heart disease

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Wahadat, A. R., Tanis, W., Scholtens, A. M., Bekker, M., Graven, L. H., Swart, L. E., den Harder, A. M., Lam, M. G. E. H., de Heer, L. M., Roos-Hesselink, J. W., & Budde, R. P. J. (2021). Normal imaging findings after aortic valve implantation on ¹⁸F-Fluorodeoxyglucose positron emission tomography with computed tomography. Journal of Nuclear Cardiology, 28(5), 2258-2268. https://doi.org/10.1007/s12350-019-02025-y

@article{f01df314d7704524b8ce2330a442771c,

title = "Normal imaging findings after aortic valve implantation on 18F-Fluorodeoxyglucose positron emission tomography with computed tomography",

abstract = "BACKGROUND: To determine the normal perivalvular 18F-Fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography (PET) with computed tomography (CT) within one year after aortic prosthetic heart valve (PHV) implantation.METHODS: Patients with uncomplicated aortic PHV implantation were prospectively included and underwent 18F-FDG PET/CT at either 5 (± 1) weeks (group 1), 12 (± 2) weeks (group 2) or 52 (± 8) weeks (group 3) after implantation. 18F-FDG uptake around the PHV was scored qualitatively (none/low/intermediate/high) and quantitatively by measuring the maximum Standardized Uptake Value (SUVmax) and target to background ratio (SUVratio).RESULTS: In total, 37 patients (group 1: n = 12, group 2: n = 12, group 3: n = 13) (mean age 66 ± 8 years) were prospectively included. Perivalvular 18F-FDG uptake was low (8/12 (67\%)) and intermediate (4/12 (33\%)) in group 1, low (7/12 (58\%)) and intermediate (5/12 (42\%)) in group 2, and low (8/13 (62\%)) and intermediate (5/13 (38\%)) in group 3 (P = 0.91). SUVmax was 4.1 ± 0.7, 4.6 ± 0.9 and 3.8 ± 0.7 (mean ± SD, P = 0.08), and SUVratio was 2.0 [1.9 to 2.2], 2.0 [1.8 to 2.6], and 1.9 [1.7 to 2.0] (median [IQR], P = 0.81) for groups 1, 2, and 3, respectively.CONCLUSION: Non-infected aortic PHV have similar low to intermediate perivalvular 18F-FDG uptake with similar SUVmax and SUVratio at 5, 12, and 52 weeks after implantation.",

keywords = "Image interpretation, Infection, Inflammation, PET, Valvular heart disease",

author = "Wahadat, \{Ali R\} and Wilco Tanis and Scholtens, \{Asbj{\o}rn M\} and Margreet Bekker and Graven, \{Laura H\} and Swart, \{Laurens E\} and \{den Harder\}, \{Annemarie M\} and Lam, \{Marnix G E H\} and \{de Heer\}, \{Linda M\} and Roos-Hesselink, \{Jolien W\} and Budde, \{Ricardo P J\}",

note = "Funding Information: The study was partially funded by a Grant of the Dutch Heart Foundation (NHF 2013T071) and Stichting Coolsingel (Project 527). Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2021",

month = oct,

doi = "10.1007/s12350-019-02025-y",

language = "English",

volume = "28",

pages = "2258--2268",

journal = "Journal of Nuclear Cardiology",

issn = "1071-3581",

publisher = "American Society of Nuclear Cardiology",

number = "5",

}

Wahadat, AR, Tanis, W, Scholtens, AM, Bekker, M, Graven, LH, Swart, LE, den Harder, AM, Lam, MGEH, de Heer, LM, Roos-Hesselink, JW & Budde, RPJ 2021, 'Normal imaging findings after aortic valve implantation on ¹⁸F-Fluorodeoxyglucose positron emission tomography with computed tomography', Journal of Nuclear Cardiology, vol. 28, no. 5, pp. 2258-2268. https://doi.org/10.1007/s12350-019-02025-y

TY - JOUR

T1 - Normal imaging findings after aortic valve implantation on 18F-Fluorodeoxyglucose positron emission tomography with computed tomography

AU - Wahadat, Ali R

AU - Tanis, Wilco

AU - Scholtens, Asbjørn M

AU - Bekker, Margreet

AU - Graven, Laura H

AU - Swart, Laurens E

AU - den Harder, Annemarie M

AU - Lam, Marnix G E H

AU - de Heer, Linda M

AU - Roos-Hesselink, Jolien W

AU - Budde, Ricardo P J

PY - 2021/10

Y1 - 2021/10

N2 - BACKGROUND: To determine the normal perivalvular 18F-Fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography (PET) with computed tomography (CT) within one year after aortic prosthetic heart valve (PHV) implantation.METHODS: Patients with uncomplicated aortic PHV implantation were prospectively included and underwent 18F-FDG PET/CT at either 5 (± 1) weeks (group 1), 12 (± 2) weeks (group 2) or 52 (± 8) weeks (group 3) after implantation. 18F-FDG uptake around the PHV was scored qualitatively (none/low/intermediate/high) and quantitatively by measuring the maximum Standardized Uptake Value (SUVmax) and target to background ratio (SUVratio).RESULTS: In total, 37 patients (group 1: n = 12, group 2: n = 12, group 3: n = 13) (mean age 66 ± 8 years) were prospectively included. Perivalvular 18F-FDG uptake was low (8/12 (67%)) and intermediate (4/12 (33%)) in group 1, low (7/12 (58%)) and intermediate (5/12 (42%)) in group 2, and low (8/13 (62%)) and intermediate (5/13 (38%)) in group 3 (P = 0.91). SUVmax was 4.1 ± 0.7, 4.6 ± 0.9 and 3.8 ± 0.7 (mean ± SD, P = 0.08), and SUVratio was 2.0 [1.9 to 2.2], 2.0 [1.8 to 2.6], and 1.9 [1.7 to 2.0] (median [IQR], P = 0.81) for groups 1, 2, and 3, respectively.CONCLUSION: Non-infected aortic PHV have similar low to intermediate perivalvular 18F-FDG uptake with similar SUVmax and SUVratio at 5, 12, and 52 weeks after implantation.

AB - BACKGROUND: To determine the normal perivalvular 18F-Fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography (PET) with computed tomography (CT) within one year after aortic prosthetic heart valve (PHV) implantation.METHODS: Patients with uncomplicated aortic PHV implantation were prospectively included and underwent 18F-FDG PET/CT at either 5 (± 1) weeks (group 1), 12 (± 2) weeks (group 2) or 52 (± 8) weeks (group 3) after implantation. 18F-FDG uptake around the PHV was scored qualitatively (none/low/intermediate/high) and quantitatively by measuring the maximum Standardized Uptake Value (SUVmax) and target to background ratio (SUVratio).RESULTS: In total, 37 patients (group 1: n = 12, group 2: n = 12, group 3: n = 13) (mean age 66 ± 8 years) were prospectively included. Perivalvular 18F-FDG uptake was low (8/12 (67%)) and intermediate (4/12 (33%)) in group 1, low (7/12 (58%)) and intermediate (5/12 (42%)) in group 2, and low (8/13 (62%)) and intermediate (5/13 (38%)) in group 3 (P = 0.91). SUVmax was 4.1 ± 0.7, 4.6 ± 0.9 and 3.8 ± 0.7 (mean ± SD, P = 0.08), and SUVratio was 2.0 [1.9 to 2.2], 2.0 [1.8 to 2.6], and 1.9 [1.7 to 2.0] (median [IQR], P = 0.81) for groups 1, 2, and 3, respectively.CONCLUSION: Non-infected aortic PHV have similar low to intermediate perivalvular 18F-FDG uptake with similar SUVmax and SUVratio at 5, 12, and 52 weeks after implantation.

KW - Image interpretation

KW - Infection

KW - Inflammation

KW - PET

KW - Valvular heart disease

UR - https://www.scopus.com/pages/publications/85078088962

U2 - 10.1007/s12350-019-02025-y

DO - 10.1007/s12350-019-02025-y

M3 - Article

C2 - 31975327

SN - 1071-3581

VL - 28

SP - 2258

EP - 2268

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

IS - 5

ER -

Normal imaging findings after aortic valve implantation on ¹⁸F-Fluorodeoxyglucose positron emission tomography with computed tomography

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