TY - JOUR
T1 - Normal Aging Brain Collection Amsterdam (NABCA)
T2 - A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls
AU - Jonkman, Laura E.
AU - Graaf, Yvon Galis de
AU - Bulk, Marjolein
AU - Kaaij, Eliane
AU - Pouwels, Petra J.W.
AU - Barkhof, Frederik
AU - Rozemuller, Annemieke J.M.
AU - van der Weerd, Louise
AU - Geurts, Jeroen J.G.
AU - van de Berg, Wilma D.J.
N1 - Funding Information:
This work was supported by Amsterdam Neuroscience , Netherlands [ 1-BI-2013 and 1-PoC-BI-2017 ]. FB is supported by the NIHR biomedical research centre at UCLH.
Publisher Copyright:
© 2019 The Authors
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.
AB - Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7 Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience.
KW - Brain banking
KW - MRI
KW - Neuropathology
KW - Non-neurological controls
KW - Brain/diagnostic imaging
KW - Magnetic Resonance Imaging
KW - Tissue Banks
KW - Netherlands
KW - Datasets as Topic
KW - Autopsy
KW - Humans
KW - Databases, Factual
UR - http://www.scopus.com/inward/record.url?scp=85060850020&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2019.101698
DO - 10.1016/j.nicl.2019.101698
M3 - Article
C2 - 30711684
AN - SCOPUS:85060850020
SN - 2213-1582
VL - 22
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 101698
ER -