Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome

Elizabeth M Kang, Moniek de Witte, Harry Malech, Richard A. Morgan, Sheila Phang, Charles Carter, Susan F Leitman, Richard W Childs, A John Barrett, Richard Little, John F Tisdale

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

To assess the safety and efficacy of nonmyeloablative allogeneic transplantation in patients with HIV infection, a clinical protocol was initiated in patients with refractory hematologic malignancies and concomitant HIV infection. The results from the first 2 patients are reported. The indications for transplantation were treatment-related acute myelogenous leukemia and primary refractory Hodgkin disease in patients 1 and 2, respectively. Only patient 1 received genetically modified cells. Both patients tolerated the procedure well with minimal toxicity, and complete remissions were achieved in both patients, but patient 2 died of relapsed Hodgkin disease 12 months after transplantation. Patient 1 continues in complete remission with undetectable HIV levels and rising CD4 counts, and with both the therapeutic and control gene transfer vectors remaining detectable at low levels more than 2 years after transplantation. These results suggest that nonmyeloablative allogeneic transplantation in the context of highly active antiretroviral therapy is feasible in patients with treatment-sensitive HIV infection.

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalBlood
Volume99
Issue number2
Publication statusPublished - 15 Jan 2002

Keywords

  • Acquired Immunodeficiency Syndrome
  • Acute Disease
  • Adult
  • Anti-Bacterial Agents
  • Antiretroviral Therapy, Highly Active
  • Cyclophosphamide
  • Cyclosporine
  • Feasibility Studies
  • Ganciclovir
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • Hodgkin Disease
  • Humans
  • Infection Control
  • Leukemia, Myeloid
  • Prednisone
  • Premedication
  • Recurrence
  • Remission Induction
  • Transplantation Conditioning
  • Treatment Outcome
  • Vidarabine
  • Viral Load
  • Journal Article

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