Non-traumatic keratitis due to Colletotrichum truncatum

Reina Llamos; Abdullah M S Al-Hatmi; Gerardo Martínez; Ferry Hagen; Rosario Velar; Alexeide de la Caridad Castillo Pérez; Jacques F Meis; María T Illnait-Zaragozí

doi:10.1099/jmmcr.0.005047

Non-traumatic keratitis due to Colletotrichum truncatum

Reina Llamos
, Abdullah M S Al-Hatmi
, Gerardo Martínez
, Ferry Hagen
, Rosario Velar
, Alexeide de la Caridad Castillo Pérez
, Jacques F Meis^*
, María T Illnait-Zaragozí

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: The fungal genus Colletotrichum is an uncommon cause of human infections. It has been implicated in cutaneous phaeohyphomycosis, artritis and keratitis secondary to traumatic implantation.

CASE PRESENTATION: We report two cases of keratitis due Colletotrichum truncatum in middle-aged, immunocompetent persons without history of trauma. The aetiological agents were identified based on DNA sequencing. Azoles and echinocandins showed high minimal inhibitory concentrations while amphotericin B was ≤ 0.25 mg l-1. Both patients failed topical antifungal treatment and needed penetrating keratoplasty with a favourable outcome.

CONCLUSION: C. truncatum caused keratomycosis which did not respond to topical antifungal agents. To the best of our knowledge these are the first reported cases of keratitis due to this fungus in Cuba and Latin-America and highlights the expanding spectrum of fungal agents causing eye infections.

Original language	English
Pages (from-to)	e005047
Journal	JMM Case Reports
Volume	3
Issue number	4
DOIs	https://doi.org/10.1099/jmmcr.0.005047
Publication status	Published - Aug 2016
Externally published	Yes

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title = "Non-traumatic keratitis due to Colletotrichum truncatum",

abstract = "INTRODUCTION: The fungal genus Colletotrichum is an uncommon cause of human infections. It has been implicated in cutaneous phaeohyphomycosis, artritis and keratitis secondary to traumatic implantation.CASE PRESENTATION: We report two cases of keratitis due Colletotrichum truncatum in middle-aged, immunocompetent persons without history of trauma. The aetiological agents were identified based on DNA sequencing. Azoles and echinocandins showed high minimal inhibitory concentrations while amphotericin B was ≤ 0.25 mg l-1. Both patients failed topical antifungal treatment and needed penetrating keratoplasty with a favourable outcome.CONCLUSION: C. truncatum caused keratomycosis which did not respond to topical antifungal agents. To the best of our knowledge these are the first reported cases of keratitis due to this fungus in Cuba and Latin-America and highlights the expanding spectrum of fungal agents causing eye infections.",

author = "Reina Llamos and Al-Hatmi, \{Abdullah M S\} and Gerardo Mart{\'i}nez and Ferry Hagen and Rosario Velar and \{de la Caridad Castillo P{\'e}rez\}, Alexeide and Meis, \{Jacques F\} and Illnait-Zaragoz{\'i}, \{Mar{\'i}a T\}",

year = "2016",

month = aug,

doi = "10.1099/jmmcr.0.005047",

language = "English",

volume = "3",

pages = "e005047",

journal = "JMM Case Reports",

issn = "2053-3721",

publisher = "Microbiology Society",

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T1 - Non-traumatic keratitis due to Colletotrichum truncatum

AU - Llamos, Reina

AU - Al-Hatmi, Abdullah M S

AU - Martínez, Gerardo

AU - Hagen, Ferry

AU - Velar, Rosario

AU - de la Caridad Castillo Pérez, Alexeide

AU - Meis, Jacques F

AU - Illnait-Zaragozí, María T

PY - 2016/8

Y1 - 2016/8

N2 - INTRODUCTION: The fungal genus Colletotrichum is an uncommon cause of human infections. It has been implicated in cutaneous phaeohyphomycosis, artritis and keratitis secondary to traumatic implantation.CASE PRESENTATION: We report two cases of keratitis due Colletotrichum truncatum in middle-aged, immunocompetent persons without history of trauma. The aetiological agents were identified based on DNA sequencing. Azoles and echinocandins showed high minimal inhibitory concentrations while amphotericin B was ≤ 0.25 mg l-1. Both patients failed topical antifungal treatment and needed penetrating keratoplasty with a favourable outcome.CONCLUSION: C. truncatum caused keratomycosis which did not respond to topical antifungal agents. To the best of our knowledge these are the first reported cases of keratitis due to this fungus in Cuba and Latin-America and highlights the expanding spectrum of fungal agents causing eye infections.

AB - INTRODUCTION: The fungal genus Colletotrichum is an uncommon cause of human infections. It has been implicated in cutaneous phaeohyphomycosis, artritis and keratitis secondary to traumatic implantation.CASE PRESENTATION: We report two cases of keratitis due Colletotrichum truncatum in middle-aged, immunocompetent persons without history of trauma. The aetiological agents were identified based on DNA sequencing. Azoles and echinocandins showed high minimal inhibitory concentrations while amphotericin B was ≤ 0.25 mg l-1. Both patients failed topical antifungal treatment and needed penetrating keratoplasty with a favourable outcome.CONCLUSION: C. truncatum caused keratomycosis which did not respond to topical antifungal agents. To the best of our knowledge these are the first reported cases of keratitis due to this fungus in Cuba and Latin-America and highlights the expanding spectrum of fungal agents causing eye infections.

U2 - 10.1099/jmmcr.0.005047

DO - 10.1099/jmmcr.0.005047

M3 - Article

C2 - 28348770

SN - 2053-3721

VL - 3

SP - e005047

JO - JMM Case Reports

JF - JMM Case Reports

IS - 4

ER -

Non-traumatic keratitis due to Colletotrichum truncatum

Abstract

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