Non-invasive Angiographic-based Fractional Flow Reserve: Technical Development, Clinical Implications, and Future Perspectives

Joyce Peper; Michiel L Bots; Tim Leiner; Martin J Swaans

doi:10.1007/s11596-023-2751-4

Non-invasive Angiographic-based Fractional Flow Reserve: Technical Development, Clinical Implications, and Future Perspectives

Joyce Peper, Michiel L Bots, Tim Leiner, Martin J Swaans

Research output: Contribution to journal › Review article › peer-review

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Abstract

New non- and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve (FFR) for the assessment of potentially significant stenosis in the coronary arteries. Virtual FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR measurements. This review provides an overview of the developments and validation of the virtual FFR-algorithms, states the challenges, discusses the upcoming clinical trials, and postulates the future role of virtual FFR in the clinical practice.

Original language	English
Pages (from-to)	423-433
Number of pages	11
Journal	Current medical science
Volume	43
Issue number	3
DOIs	https://doi.org/10.1007/s11596-023-2751-4
Publication status	Published - Jun 2023

Keywords

Coronary Angiography/methods
Coronary Stenosis/diagnostic imaging
Coronary Vessels/diagnostic imaging
Fractional Flow Reserve, Myocardial
Humans
Predictive Value of Tests
coronary artery disease
diagnostic accuracy
quantitative flow ratio
physiology guided percutaneous coronary intervention
fractional flow reserve

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s11596-023-2751-4Final published version, 666 KBLicence: CC BY

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title = "Non-invasive Angiographic-based Fractional Flow Reserve: Technical Development, Clinical Implications, and Future Perspectives",

abstract = "New non- and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve (FFR) for the assessment of potentially significant stenosis in the coronary arteries. Virtual FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR measurements. This review provides an overview of the developments and validation of the virtual FFR-algorithms, states the challenges, discusses the upcoming clinical trials, and postulates the future role of virtual FFR in the clinical practice.",

keywords = "Coronary Angiography/methods, Coronary Stenosis/diagnostic imaging, Coronary Vessels/diagnostic imaging, Fractional Flow Reserve, Myocardial, Humans, Predictive Value of Tests, coronary artery disease, diagnostic accuracy, quantitative flow ratio, physiology guided percutaneous coronary intervention, fractional flow reserve",

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year = "2023",

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doi = "10.1007/s11596-023-2751-4",

language = "English",

volume = "43",

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AU - Bots, Michiel L

AU - Leiner, Tim

AU - Swaans, Martin J

PY - 2023/6

Y1 - 2023/6

N2 - New non- and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve (FFR) for the assessment of potentially significant stenosis in the coronary arteries. Virtual FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR measurements. This review provides an overview of the developments and validation of the virtual FFR-algorithms, states the challenges, discusses the upcoming clinical trials, and postulates the future role of virtual FFR in the clinical practice.

AB - New non- and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve (FFR) for the assessment of potentially significant stenosis in the coronary arteries. Virtual FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR measurements. This review provides an overview of the developments and validation of the virtual FFR-algorithms, states the challenges, discusses the upcoming clinical trials, and postulates the future role of virtual FFR in the clinical practice.

KW - Coronary Angiography/methods

KW - Coronary Stenosis/diagnostic imaging

KW - Coronary Vessels/diagnostic imaging

KW - Fractional Flow Reserve, Myocardial

KW - Humans

KW - Predictive Value of Tests

KW - coronary artery disease

KW - diagnostic accuracy

KW - quantitative flow ratio

KW - physiology guided percutaneous coronary intervention

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VL - 43

SP - 423

EP - 433

JO - Current medical science

JF - Current medical science

IS - 3

ER -

Non-invasive Angiographic-based Fractional Flow Reserve: Technical Development, Clinical Implications, and Future Perspectives

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