Non-invasive Angiographic-based Fractional Flow Reserve: Technical Development, Clinical Implications, and Future Perspectives

Joyce Peper, Michiel L Bots, Tim Leiner, Martin J Swaans

Research output: Contribution to journalReview articlepeer-review

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Abstract

New non- and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve (FFR) for the assessment of potentially significant stenosis in the coronary arteries. Virtual FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR measurements. This review provides an overview of the developments and validation of the virtual FFR-algorithms, states the challenges, discusses the upcoming clinical trials, and postulates the future role of virtual FFR in the clinical practice.

Original languageEnglish
Pages (from-to)423-433
Number of pages11
JournalCurrent medical science
Volume43
Issue number3
DOIs
Publication statusPublished - Jun 2023

Keywords

  • Coronary Angiography/methods
  • Coronary Stenosis/diagnostic imaging
  • Coronary Vessels/diagnostic imaging
  • Fractional Flow Reserve, Myocardial
  • Humans
  • Predictive Value of Tests
  • coronary artery disease
  • diagnostic accuracy
  • quantitative flow ratio
  • physiology guided percutaneous coronary intervention
  • fractional flow reserve

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