Nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT

J W Braams; J Pruim; P G Nikkels; J L Roodenburg; W Vaalburg; A Vermey

Nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT

J W Braams
, J Pruim
, P G Nikkels
, J L Roodenburg
, W Vaalburg
, A Vermey

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

UNLABELLED: The uptake of L-1-[11C]-tyrosine (TYR) in cervical lymph nodes of eleven patients with squamous-cell carcinoma (SCC) of the oral cavity was studied with PET to detect lymphogenic metastases.

METHODS: The TYR-PET results were compared with clinical, MRI, CT, histopathologic findings and historical data of patients studied with FDG. Sensitivity, specificity, accuracy and the positive and negative predictive values were calculated.

RESULTS: TYR-PET had sensitivity of 83% and a specificity of 95%. In contrast, the sensitivity and specificity for MRI were 33% and 96%, respectively. The sensitivity and specificity for CT were 55% and 91%, respectively. TYR-PET results compared favorably with FDG.

CONCLUSION: With TYR-PET, SCC metastases of the oral cavity can be visualized with high sensitivity and specificity. TYR-PET can be an additional tool for further evaluation of neck malignancies.

Original language	English
Pages (from-to)	897-901
Number of pages	5
Journal	Journal of Nuclear Medicine
Volume	37
Issue number	6
Publication status	Published - Jun 1996

Keywords

Aged
Carbon Radioisotopes
Carcinoma, Squamous Cell
Female
Humans
Lymph Nodes
Lymphatic Metastasis
Magnetic Resonance Imaging
Male
Middle Aged
Mouth Neoplasms
Predictive Value of Tests
Sensitivity and Specificity
Tomography, Emission-Computed
Tomography, X-Ray Computed
Tyrosine

Cite this

@article{4791a209702546dfa8e3da3b9a4cd25f,

title = "Nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT",

abstract = "UNLABELLED: The uptake of L-1-[11C]-tyrosine (TYR) in cervical lymph nodes of eleven patients with squamous-cell carcinoma (SCC) of the oral cavity was studied with PET to detect lymphogenic metastases.METHODS: The TYR-PET results were compared with clinical, MRI, CT, histopathologic findings and historical data of patients studied with FDG. Sensitivity, specificity, accuracy and the positive and negative predictive values were calculated.RESULTS: TYR-PET had sensitivity of 83\% and a specificity of 95\%. In contrast, the sensitivity and specificity for MRI were 33\% and 96\%, respectively. The sensitivity and specificity for CT were 55\% and 91\%, respectively. TYR-PET results compared favorably with FDG.CONCLUSION: With TYR-PET, SCC metastases of the oral cavity can be visualized with high sensitivity and specificity. TYR-PET can be an additional tool for further evaluation of neck malignancies.",

keywords = "Aged, Carbon Radioisotopes, Carcinoma, Squamous Cell, Female, Humans, Lymph Nodes, Lymphatic Metastasis, Magnetic Resonance Imaging, Male, Middle Aged, Mouth Neoplasms, Predictive Value of Tests, Sensitivity and Specificity, Tomography, Emission-Computed, Tomography, X-Ray Computed, Tyrosine",

author = "Braams, \{J W\} and J Pruim and Nikkels, \{P G\} and Roodenburg, \{J L\} and W Vaalburg and A Vermey",

year = "1996",

month = jun,

language = "English",

volume = "37",

pages = "897--901",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

number = "6",

}

TY - JOUR

T1 - Nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT

AU - Braams, J W

AU - Pruim, J

AU - Nikkels, P G

AU - Roodenburg, J L

AU - Vaalburg, W

AU - Vermey, A

PY - 1996/6

Y1 - 1996/6

N2 - UNLABELLED: The uptake of L-1-[11C]-tyrosine (TYR) in cervical lymph nodes of eleven patients with squamous-cell carcinoma (SCC) of the oral cavity was studied with PET to detect lymphogenic metastases.METHODS: The TYR-PET results were compared with clinical, MRI, CT, histopathologic findings and historical data of patients studied with FDG. Sensitivity, specificity, accuracy and the positive and negative predictive values were calculated.RESULTS: TYR-PET had sensitivity of 83% and a specificity of 95%. In contrast, the sensitivity and specificity for MRI were 33% and 96%, respectively. The sensitivity and specificity for CT were 55% and 91%, respectively. TYR-PET results compared favorably with FDG.CONCLUSION: With TYR-PET, SCC metastases of the oral cavity can be visualized with high sensitivity and specificity. TYR-PET can be an additional tool for further evaluation of neck malignancies.

AB - UNLABELLED: The uptake of L-1-[11C]-tyrosine (TYR) in cervical lymph nodes of eleven patients with squamous-cell carcinoma (SCC) of the oral cavity was studied with PET to detect lymphogenic metastases.METHODS: The TYR-PET results were compared with clinical, MRI, CT, histopathologic findings and historical data of patients studied with FDG. Sensitivity, specificity, accuracy and the positive and negative predictive values were calculated.RESULTS: TYR-PET had sensitivity of 83% and a specificity of 95%. In contrast, the sensitivity and specificity for MRI were 33% and 96%, respectively. The sensitivity and specificity for CT were 55% and 91%, respectively. TYR-PET results compared favorably with FDG.CONCLUSION: With TYR-PET, SCC metastases of the oral cavity can be visualized with high sensitivity and specificity. TYR-PET can be an additional tool for further evaluation of neck malignancies.

KW - Aged

KW - Carbon Radioisotopes

KW - Carcinoma, Squamous Cell

KW - Female

KW - Humans

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Mouth Neoplasms

KW - Predictive Value of Tests

KW - Sensitivity and Specificity

KW - Tomography, Emission-Computed

KW - Tomography, X-Ray Computed

KW - Tyrosine

M3 - Article

C2 - 8683307

SN - 0161-5505

VL - 37

SP - 897

EP - 901

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 6

ER -

Nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT

Abstract

Keywords

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