No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke

Marjolein Geurts; HB van der Worp; Alexander D. Horsch; L. Jaap Kappelle; Geert J. Biessels; BK Velthuis

doi:10.1371/journal.pone.0140777

No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke

Marjolein Geurts^*, HB van der Worp, Alexander D. Horsch, L. Jaap Kappelle, Geert J. Biessels, BK Velthuis,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background

Recanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.

Methods

We included 278 patients with acute ischaemic stroke within nine hours after symptom onset, who had an intracranial arterial occlusion on admission CT angiography, in 13 participating centres. We calculated the relation per every 0.1 degrees Celsius increase in admission body temperature and recanalization at three days.

Results

Recanalization occurred in 80% of occluded arteries. There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1 degrees Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70). Results for patients treated or not treated with alteplase were essentially the same.

Conclusions

Our findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

Original language	English
Article number	e0140777
Number of pages	6
Journal	PLoS ONE [E]
Volume	10
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0140777
Publication status	Published - 16 Oct 2015

Keywords

THERAPEUTIC HYPOTHERMIA
ASSOCIATION
GUIDELINES
MANAGEMENT
BENEFIT

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title = "No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke",

abstract = "BackgroundRecanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.MethodsWe included 278 patients with acute ischaemic stroke within nine hours after symptom onset, who had an intracranial arterial occlusion on admission CT angiography, in 13 participating centres. We calculated the relation per every 0.1 degrees Celsius increase in admission body temperature and recanalization at three days.ResultsRecanalization occurred in 80% of occluded arteries. There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1 degrees Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70). Results for patients treated or not treated with alteplase were essentially the same.ConclusionsOur findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.",

keywords = "THERAPEUTIC HYPOTHERMIA, ASSOCIATION, GUIDELINES, MANAGEMENT, BENEFIT",

author = "Marjolein Geurts and {van der Worp}, HB and Horsch, {Alexander D.} and Kappelle, {L. Jaap} and Biessels, {Geert J.} and BK Velthuis",

year = "2015",

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doi = "10.1371/journal.pone.0140777",

language = "English",

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T1 - No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke

AU - Geurts, Marjolein

AU - van der Worp, HB

AU - Horsch, Alexander D.

AU - Kappelle, L. Jaap

AU - Biessels, Geert J.

AU - Velthuis, BK

PY - 2015/10/16

Y1 - 2015/10/16

N2 - BackgroundRecanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.MethodsWe included 278 patients with acute ischaemic stroke within nine hours after symptom onset, who had an intracranial arterial occlusion on admission CT angiography, in 13 participating centres. We calculated the relation per every 0.1 degrees Celsius increase in admission body temperature and recanalization at three days.ResultsRecanalization occurred in 80% of occluded arteries. There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1 degrees Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70). Results for patients treated or not treated with alteplase were essentially the same.ConclusionsOur findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

AB - BackgroundRecanalization of an occluded intracranial artery is influenced by temperature-dependent enzymes, including alteplase. We assessed the relation between body temperature on admission and recanalization.MethodsWe included 278 patients with acute ischaemic stroke within nine hours after symptom onset, who had an intracranial arterial occlusion on admission CT angiography, in 13 participating centres. We calculated the relation per every 0.1 degrees Celsius increase in admission body temperature and recanalization at three days.ResultsRecanalization occurred in 80% of occluded arteries. There was no relation between body temperature and recanalization at three days after adjustments for age, NIHSS score on admission and treatment with alteplase (adjusted odds ratio per 0.1 degrees Celsius, 0.99; 95% confidence interval, 0.94-1.05; p = 0.70). Results for patients treated or not treated with alteplase were essentially the same.ConclusionsOur findings suggest that in patients with acute ischaemic stroke there is no relation between body temperature on admission and recanalization of an occluded intracranial artery three days later, irrespective of treatment with alteplase.

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No Relation between Body Temperature and Arterial Recanalization at Three Days in Patients with Acute Ischaemic Stroke

Abstract

Keywords

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