No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

Gijsje Snijders; Maarten J. Titulaer; Veerle Bergink; Anna E. Bastiaansen; Marco W.J. Schreurs; Roel A. Ophoff; Marco P. Boks; René S. Kahn; Lot D. de Witte

doi:10.1016/j.psychres.2017.10.043

No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

Gijsje Snijders^*
, Maarten J. Titulaer
, Veerle Bergink
, Anna E. Bastiaansen
, Marco W.J. Schreurs
, Roel A. Ophoff
, Marco P. Boks
, René S. Kahn
, Lot D. de Witte

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

Original language	English
Pages (from-to)	460-462
Number of pages	3
Journal	Psychiatry Research
Volume	259
DOIs	https://doi.org/10.1016/j.psychres.2017.10.043
Publication status	Published - 1 Jan 2018

Keywords

Antibodies
Autoimmune
Bipolar disorder
Encephalitis
Immunology
Mania

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title = "No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder",

abstract = "A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1\%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.",

keywords = "Antibodies, Autoimmune, Bipolar disorder, Encephalitis, Immunology, Mania",

author = "Gijsje Snijders and Titulaer, \{Maarten J.\} and Veerle Bergink and Bastiaansen, \{Anna E.\} and Schreurs, \{Marco W.J.\} and Ophoff, \{Roel A.\} and Boks, \{Marco P.\} and Kahn, \{Ren{\'e} S.\} and \{de Witte\}, \{Lot D.\}",

note = "Funding Information: This project is supported by a 2014 NARSAD Young Investigator Grant from the Brain \& Behavior Research Foundation (grant no. 22979 ), and a Memorabel fellowship by the Netherlands Organisation for Scientific Research (NWO, Titulaer). The Dutch Bipolar Cohort study was funded by NIH/NIMH R01 MH090553 (Ophoff). These organizations had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. The authors have no financial relationships to disclose. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

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doi = "10.1016/j.psychres.2017.10.043",

language = "English",

volume = "259",

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AU - Snijders, Gijsje

AU - Titulaer, Maarten J.

AU - Bergink, Veerle

AU - Bastiaansen, Anna E.

AU - Schreurs, Marco W.J.

AU - Ophoff, Roel A.

AU - Boks, Marco P.

AU - Kahn, René S.

AU - de Witte, Lot D.

N1 - Funding Information: This project is supported by a 2014 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation (grant no. 22979 ), and a Memorabel fellowship by the Netherlands Organisation for Scientific Research (NWO, Titulaer). The Dutch Bipolar Cohort study was funded by NIH/NIMH R01 MH090553 (Ophoff). These organizations had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. The authors have no financial relationships to disclose. Publisher Copyright: © 2017 Elsevier B.V.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

AB - A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

KW - Antibodies

KW - Autoimmune

KW - Bipolar disorder

KW - Encephalitis

KW - Immunology

KW - Mania

UR - https://www.scopus.com/pages/publications/85033389192

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VL - 259

SP - 460

EP - 462

JO - Psychiatry Research

JF - Psychiatry Research

ER -

No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder

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Keywords

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