No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

Hans C. van Mierlo; Marleen H. van Coevorden-Hameete; Leon P. Munting; Esther de Graaff; Lot de Witte; Richard Bruggeman; Wiepke Cahn; Lieuwe de Haan; René S. Kahn; Carin J. Meijer; Inez Myin-Germeys; Jim van Os; Durk Wiersma

doi:10.1016/j.euroneuro.2015.09.017

No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

Hans C. van Mierlo^*, Marleen H. van Coevorden-Hameete, Leon P. Munting, Esther de Graaff, Lot de Witte, Richard Bruggeman, Wiepke Cahn, Lieuwe de Haan, René S. Kahn, Carin J. Meijer, Inez Myin-Germeys, Jim van Os, Durk Wiersma,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.

Original language	English
Pages (from-to)	2326-2332
Number of pages	7
Journal	European Neuropsychopharmacology
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.euroneuro.2015.09.017
Publication status	Published - 1 Dec 2015

Keywords

Antibodies
Autoimmune
Encephalitis
Immunology
Psychosis
Schizophrenia

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10.1016/j.euroneuro.2015.09.017

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van Mierlo, H. C., van Coevorden-Hameete, M. H., Munting, L. P., de Graaff, E., de Witte, L., Bruggeman, R., Cahn, W., de Haan, L., Kahn, R. S., Meijer, C. J., Myin-Germeys, I., van Os, J., Wiersma, D. (2015). No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia. European Neuropsychopharmacology, 25(12), 2326-2332. https://doi.org/10.1016/j.euroneuro.2015.09.017

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title = "No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia",

abstract = "The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.",

keywords = "Antibodies, Autoimmune, Encephalitis, Immunology, Psychosis, Schizophrenia",

author = "{van Mierlo}, {Hans C.} and {van Coevorden-Hameete}, {Marleen H.} and Munting, {Leon P.} and {de Graaff}, Esther and {de Witte}, Lot and Richard Bruggeman and Wiepke Cahn and {de Haan}, Lieuwe and Kahn, {Ren{\'e} S.} and Meijer, {Carin J.} and Inez Myin-Germeys and {van Os}, Jim and Durk Wiersma",

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doi = "10.1016/j.euroneuro.2015.09.017",

language = "English",

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van Mierlo, HC, van Coevorden-Hameete, MH, Munting, LP, de Graaff, E, de Witte, L, Bruggeman, R, Cahn, W, de Haan, L, Kahn, RS, Meijer, CJ, Myin-Germeys, I, van Os, J, Wiersma, D 2015, 'No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia', European Neuropsychopharmacology, vol. 25, no. 12, pp. 2326-2332. https://doi.org/10.1016/j.euroneuro.2015.09.017

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T1 - No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

AU - van Mierlo, Hans C.

AU - van Coevorden-Hameete, Marleen H.

AU - Munting, Leon P.

AU - de Graaff, Esther

AU - de Witte, Lot

AU - Bruggeman, Richard

AU - Cahn, Wiepke

AU - de Haan, Lieuwe

AU - Kahn, René S.

AU - Meijer, Carin J.

AU - Myin-Germeys, Inez

AU - van Os, Jim

AU - Wiersma, Durk

PY - 2015/12/1

Y1 - 2015/12/1

N2 - The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.

AB - The immune system has been implicated in the etiology of schizophrenia. Autoimmunity by antibodies against neuronal cell surface antigens has been proposed as one of the pathological mechanisms. We examined plasma samples of 104 patients diagnosed with schizophrenia for the presence of autoantibodies against neuronal cell surface antigens using cultured hippocampal neurons and transfected HeLa cells. None of the samples tested positive for the presence of these autoantibodies. Based on our results it seems unlikely that autoantibodies against neuronal cell surface antigens play a role in the pathogenesis of schizophrenia, although further studies using cerebrospinal fluid are needed.

KW - Antibodies

KW - Autoimmune

KW - Encephalitis

KW - Immunology

KW - Psychosis

KW - Schizophrenia

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SN - 0924-977X

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EP - 2332

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 12

ER -

No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia

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Keywords

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