No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood

Jonneke J. Hollanders; Joël Israëls; Sylvia M. Van Der Pal; Paul H. Verkerk; Joost Rotteveel; Martijn J J Finken; E. T M Hille; C. H. De Groot; H. Kloosterboer-Boerrigter; A. L. Den Ouden; A. Rijpstra; S. P. Verloove-Vanhorick; J. A. Vogelaar; J. H. Kok; A. Ilsen; M. Van Der Lans; W. J C Boelen-Van Der Loo; T. Lundqvist; H. S A Heymans; E. J. Duiverman; W. B. Geven; M. L. Duiverman; L. I. Geven; E. J L E Vrijlandt; A. L M Mulder; A. Gerver; L. A A Kollée; L. Reijmers; R. Sonnemans; J. M. Wit; F. W. Dekker; M. J J Finken; N. Weisglas-Kuperus; M. G. Keijzer-Veen; A. J. Van Der Heijden; J. B. Van Goudoever; M. M. Van Weissenbruch; A. Cranendonk; H. A. Delemarre-Van De Waal; L. De Groot; J. F. Samsom; L. S. De Vries; K. J. Rademaker; E. Moerman; M. Voogsgeerd; M. J K De Kleine; P. Andriessen; C. C M Dielissen-Van Helvoirt; I. Mohamed; H. L M Van Straaten; W. Baerts; G. W. Veneklaas Slots-Kloosterboer; E. M J Tuller-Pikkemaat; M. H. Ens-Dokkum; G. J. Van Steenbrugge

doi:10.1210/jc.2015-3078

No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood

Jonneke J. Hollanders^*
, Joël Israëls
, Sylvia M. Van Der Pal
, Paul H. Verkerk
, Joost Rotteveel
, Martijn J J Finken
, E. T M Hille
, C. H. De Groot
, H. Kloosterboer-Boerrigter
, A. L. Den Ouden
, A. Rijpstra
, S. P. Verloove-Vanhorick
, J. A. Vogelaar
, J. H. Kok
, A. Ilsen
, M. Van Der Lans
, W. J C Boelen-Van Der Loo
, T. Lundqvist
, H. S A Heymans
, E. J. Duiverman

W. B. Geven, M. L. Duiverman, L. I. Geven, E. J L E Vrijlandt, A. L M Mulder, A. Gerver, L. A A Kollée, L. Reijmers, R. Sonnemans, J. M. Wit, F. W. Dekker, M. J J Finken, N. Weisglas-Kuperus, M. G. Keijzer-Veen, A. J. Van Der Heijden, J. B. Van Goudoever, M. M. Van Weissenbruch, A. Cranendonk, H. A. Delemarre-Van De Waal, L. De Groot, J. F. Samsom, L. S. De Vries, K. J. Rademaker, E. Moerman, M. Voogsgeerd, M. J K De Kleine, P. Andriessen, C. C M Dielissen-Van Helvoirt, I. Mohamed, H. L M Van Straaten, W. Baerts, G. W. Veneklaas Slots-Kloosterboer, E. M J Tuller-Pikkemaat, M. H. Ens-Dokkum, G. J. Van Steenbrugge

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood.

Objective: The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young adult age.

Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,32 wk) and/or with a very low birth weight (ie, 1500 g).

Setting: This was a multicenter study.

Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP.

Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoP was defined as a total T4 concentration< -3 SD of the daily mean (approximately 60 nmol/L).

Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen’s examination of minor neurological dysfunction, respectively.

Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, 1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics.

Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.

Original language	English
Pages (from-to)	4648-4653
Number of pages	6
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	100
Issue number	12
DOIs	https://doi.org/10.1210/jc.2015-3078
Publication status	Published - 1 Dec 2015

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Hollanders, J. J., Israëls, J., Van Der Pal, S. M., Verkerk, P. H., Rotteveel, J., Finken, M. J. J., Hille, E. T. M., De Groot, C. H., Kloosterboer-Boerrigter, H., Den Ouden, A. L., Rijpstra, A., Verloove-Vanhorick, S. P., Vogelaar, J. A., Kok, J. H., Ilsen, A., Van Der Lans, M., Boelen-Van Der Loo, W. J. C., Lundqvist, T., Heymans, H. S. A., ... Van Steenbrugge, G. J. (2015). No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood. Journal of Clinical Endocrinology and Metabolism, 100(12), 4648-4653. https://doi.org/10.1210/jc.2015-3078

@article{f1ed236be7b84de2ad0eb310b8c2ca1a,

title = "No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood",

abstract = "Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood.Objective: The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young adult age.Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,32 wk) and/or with a very low birth weight (ie, 1500 g).Setting: This was a multicenter study.Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP.Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoP was defined as a total T4 concentration< -3 SD of the daily mean (approximately 60 nmol/L).Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen{\textquoteright}s examination of minor neurological dysfunction, respectively.Results: THoP was not associated with IQ score (mean difference, 0 [95\% confidence interval,3.8 to 3.8] points) or motor function (mean difference, 0.6 [95\% confidence interval, 1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics.Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.",

author = "Hollanders, \{Jonneke J.\} and Jo{\"e}l Isra{\"e}ls and \{Van Der Pal\}, \{Sylvia M.\} and Verkerk, \{Paul H.\} and Joost Rotteveel and Finken, \{Martijn J J\} and Hille, \{E. T M\} and \{De Groot\}, \{C. H.\} and H. Kloosterboer-Boerrigter and \{Den Ouden\}, \{A. L.\} and A. Rijpstra and Verloove-Vanhorick, \{S. P.\} and Vogelaar, \{J. A.\} and Kok, \{J. H.\} and A. Ilsen and \{Van Der Lans\}, M. and \{Boelen-Van Der Loo\}, \{W. J C\} and T. Lundqvist and Heymans, \{H. S A\} and Duiverman, \{E. J.\} and Geven, \{W. B.\} and Duiverman, \{M. L.\} and Geven, \{L. I.\} and Vrijlandt, \{E. J L E\} and Mulder, \{A. L M\} and A. Gerver and Koll{\'e}e, \{L. A A\} and L. Reijmers and R. Sonnemans and Wit, \{J. M.\} and Dekker, \{F. W.\} and Finken, \{M. J J\} and N. Weisglas-Kuperus and Keijzer-Veen, \{M. G.\} and \{Van Der Heijden\}, \{A. J.\} and \{Van Goudoever\}, \{J. B.\} and \{Van Weissenbruch\}, \{M. M.\} and A. Cranendonk and \{Delemarre-Van De Waal\}, \{H. A.\} and \{De Groot\}, L. and Samsom, \{J. F.\} and \{De Vries\}, \{L. S.\} and Rademaker, \{K. J.\} and E. Moerman and M. Voogsgeerd and \{De Kleine\}, \{M. J K\} and P. Andriessen and \{Dielissen-Van Helvoirt\}, \{C. C M\} and I. Mohamed and \{Van Straaten\}, \{H. L M\} and W. Baerts and \{Veneklaas Slots-Kloosterboer\}, \{G. W.\} and Tuller-Pikkemaat, \{E. M J\} and Ens-Dokkum, \{M. H.\} and \{Van Steenbrugge\}, \{G. J.\}",

year = "2015",

month = dec,

day = "1",

doi = "10.1210/jc.2015-3078",

language = "English",

volume = "100",

pages = "4648--4653",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "Endocrine Society",

number = "12",

}

Hollanders, JJ, Israëls, J, Van Der Pal, SM, Verkerk, PH, Rotteveel, J, Finken, MJJ, Hille, ETM, De Groot, CH, Kloosterboer-Boerrigter, H, Den Ouden, AL, Rijpstra, A, Verloove-Vanhorick, SP, Vogelaar, JA, Kok, JH, Ilsen, A, Van Der Lans, M, Boelen-Van Der Loo, WJC, Lundqvist, T, Heymans, HSA, Duiverman, EJ, Geven, WB, Duiverman, ML, Geven, LI, Vrijlandt, EJLE, Mulder, ALM, Gerver, A, Kollée, LAA, Reijmers, L, Sonnemans, R, Wit, JM, Dekker, FW, Finken, MJJ, Weisglas-Kuperus, N, Keijzer-Veen, MG, Van Der Heijden, AJ, Van Goudoever, JB, Van Weissenbruch, MM, Cranendonk, A, Delemarre-Van De Waal, HA, De Groot, L, Samsom, JF, De Vries, LS, Rademaker, KJ, Moerman, E, Voogsgeerd, M, De Kleine, MJK, Andriessen, P, Dielissen-Van Helvoirt, CCM, Mohamed, I, Van Straaten, HLM, Baerts, W, Veneklaas Slots-Kloosterboer, GW, Tuller-Pikkemaat, EMJ, Ens-Dokkum, MH & Van Steenbrugge, GJ 2015, 'No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 12, pp. 4648-4653. https://doi.org/10.1210/jc.2015-3078

TY - JOUR

T1 - No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood

AU - Hollanders, Jonneke J.

AU - Israëls, Joël

AU - Van Der Pal, Sylvia M.

AU - Verkerk, Paul H.

AU - Rotteveel, Joost

AU - Finken, Martijn J J

AU - Hille, E. T M

AU - De Groot, C. H.

AU - Kloosterboer-Boerrigter, H.

AU - Den Ouden, A. L.

AU - Rijpstra, A.

AU - Verloove-Vanhorick, S. P.

AU - Vogelaar, J. A.

AU - Kok, J. H.

AU - Ilsen, A.

AU - Van Der Lans, M.

AU - Boelen-Van Der Loo, W. J C

AU - Lundqvist, T.

AU - Heymans, H. S A

AU - Duiverman, E. J.

AU - Geven, W. B.

AU - Duiverman, M. L.

AU - Geven, L. I.

AU - Vrijlandt, E. J L E

AU - Mulder, A. L M

AU - Gerver, A.

AU - Kollée, L. A A

AU - Reijmers, L.

AU - Sonnemans, R.

AU - Wit, J. M.

AU - Dekker, F. W.

AU - Finken, M. J J

AU - Weisglas-Kuperus, N.

AU - Keijzer-Veen, M. G.

AU - Van Der Heijden, A. J.

AU - Van Goudoever, J. B.

AU - Van Weissenbruch, M. M.

AU - Cranendonk, A.

AU - Delemarre-Van De Waal, H. A.

AU - De Groot, L.

AU - Samsom, J. F.

AU - De Vries, L. S.

AU - Rademaker, K. J.

AU - Moerman, E.

AU - Voogsgeerd, M.

AU - De Kleine, M. J K

AU - Andriessen, P.

AU - Dielissen-Van Helvoirt, C. C M

AU - Mohamed, I.

AU - Van Straaten, H. L M

AU - Baerts, W.

AU - Veneklaas Slots-Kloosterboer, G. W.

AU - Tuller-Pikkemaat, E. M J

AU - Ens-Dokkum, M. H.

AU - Van Steenbrugge, G. J.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood.Objective: The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young adult age.Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,32 wk) and/or with a very low birth weight (ie, 1500 g).Setting: This was a multicenter study.Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP.Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoP was defined as a total T4 concentration< -3 SD of the daily mean (approximately 60 nmol/L).Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen’s examination of minor neurological dysfunction, respectively.Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, 1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics.Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.

AB - Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood.Objective: The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young adult age.Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,32 wk) and/or with a very low birth weight (ie, 1500 g).Setting: This was a multicenter study.Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP.Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoP was defined as a total T4 concentration< -3 SD of the daily mean (approximately 60 nmol/L).Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen’s examination of minor neurological dysfunction, respectively.Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, 1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics.Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.

UR - https://www.scopus.com/pages/publications/84951183148

U2 - 10.1210/jc.2015-3078

DO - 10.1210/jc.2015-3078

M3 - Article

C2 - 26480285

AN - SCOPUS:84951183148

SN - 0021-972X

VL - 100

SP - 4648

EP - 4653

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 12

ER -

No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood

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