No association between anti-thyroidperoxidase antibodies and bipolar disorder: A study in the Dutch Bipolar Cohort and a meta-analysis

G J L J Snijders, L D de Witte, D van den Berk, C van der Laan, E Regeer, M J H Begemann, A Berdenis van Berlekom, M Litjens, M P Boks, R A Ophoff, R S Kahn, M H J Hillegers

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Abstract

BACKGROUND: Thyroid autoimmunity has been associated with bipolar disorder (BD). However, results from previous studies on the seroprevalence of anti-thyroid peroxidase antibodies (TPO-abs) in BD are inconsistent.

OBJECTIVES: The aim of the present study is to investigate whether the seroprevalence and titer levels of TPO-abs are related to BD.

METHOD: TPO-abs were measured in plasma samples of 760 patients with bipolar disorder, 261 first-degree relatives and 363 controls by enzyme-linked immunosorbent assay (ELISA). To address methodological limitations of previous studies, we assessed clinical characteristics with several (self-reported) questionnaires to investigate whether TPO-abs positivity is related to particular clinical subgroups of BD patients. We performed an additional meta-analysis of seroprevalences of TPO-abs in BD patients including data from present and previous studies.

RESULTS: Seroprevalence or titer levels of TPO-abs did not significantly differ between patients with BD, their first-degree relatives, and controls. In BD patients, the prevalence of TPO-abs was unrelated to specific clinical factors, including lithium use. Our meta-analysis of twelve studies showed an overall odds ratio of 1.3 (CI 95 %: 0.7-2.3; p = 0.30), reaffirming the absence of an association of BD with TPO-abs.

CONCLUSIONS: In the largest study of TPO-abs in BD to date, our findings indicate that TPO-abs are not associated with (the risk for) bipolar disorder.

Original languageEnglish
Article number104518
Pages (from-to)1-8
JournalPsychoneuroendocrinology
Volume112
Early online date16 Nov 2019
DOIs
Publication statusPublished - Feb 2020

Keywords

  • Antithyroid microsomal antibody
  • Bipolar disorder
  • Thyroid diseases

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