Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia

F. Groenendaal; J.S. Vles; H. Lammers; J. de Vente; D. Smit; P.G.J. Nikkels

doi:10.1159/000106432

Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia

F. Groenendaal, J.S. Vles, H. Lammers, J. de Vente, D. Smit, P.G.J. Nikkels

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Spinal cord injury has been reported after perinatal asphyxia in full-term neonates.

OBJECTIVES: To examine the role of excessive nitric oxide production in perinatal spinal cord injury.

SUBJECTS AND METHODS: Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT).

RESULTS: NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants.

CONCLUSIONS: excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Neonatology
Volume	93
Issue number	1
DOIs	https://doi.org/10.1159/000106432
Publication status	Published - 2008

Keywords

Antigens, CD
Antigens, Differentiation, Myelomonocytic
Apoptosis
Asphyxia Neonatorum
Autopsy
Caspase 3
Female
Humans
Hypoxia-Ischemia, Brain
Infant, Newborn
Inflammation
Male
Nitric Oxide
Spinal Cord
Tyrosine
Journal Article
Research Support, Non-U.S. Gov't

Access to Document

10.1159/000106432

Cite this

@article{6e566ca58c87498897194e581514f908,

title = "Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia",

abstract = "BACKGROUND: Spinal cord injury has been reported after perinatal asphyxia in full-term neonates.OBJECTIVES: To examine the role of excessive nitric oxide production in perinatal spinal cord injury.SUBJECTS AND METHODS: Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT).RESULTS: NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants.CONCLUSIONS: excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.",

keywords = "Antigens, CD, Antigens, Differentiation, Myelomonocytic, Apoptosis, Asphyxia Neonatorum, Autopsy, Caspase 3, Female, Humans, Hypoxia-Ischemia, Brain, Infant, Newborn, Inflammation, Male, Nitric Oxide, Spinal Cord, Tyrosine, Journal Article, Research Support, Non-U.S. Gov't",

author = "F. Groenendaal and J.S. Vles and H. Lammers and {de Vente}, J. and D. Smit and P.G.J. Nikkels",

year = "2008",

doi = "10.1159/000106432",

language = "English",

volume = "93",

pages = "1--6",

journal = "Neonatology",

issn = "1661-7800",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia

AU - Groenendaal, F.

AU - Vles, J.S.

AU - Lammers, H.

AU - de Vente, J.

AU - Smit, D.

AU - Nikkels, P.G.J.

PY - 2008

Y1 - 2008

N2 - BACKGROUND: Spinal cord injury has been reported after perinatal asphyxia in full-term neonates.OBJECTIVES: To examine the role of excessive nitric oxide production in perinatal spinal cord injury.SUBJECTS AND METHODS: Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT).RESULTS: NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants.CONCLUSIONS: excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.

AB - BACKGROUND: Spinal cord injury has been reported after perinatal asphyxia in full-term neonates.OBJECTIVES: To examine the role of excessive nitric oxide production in perinatal spinal cord injury.SUBJECTS AND METHODS: Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT).RESULTS: NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants.CONCLUSIONS: excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.

KW - Antigens, CD

KW - Antigens, Differentiation, Myelomonocytic

KW - Apoptosis

KW - Asphyxia Neonatorum

KW - Autopsy

KW - Caspase 3

KW - Female

KW - Humans

KW - Hypoxia-Ischemia, Brain

KW - Infant, Newborn

KW - Inflammation

KW - Male

KW - Nitric Oxide

KW - Spinal Cord

KW - Tyrosine

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1159/000106432

DO - 10.1159/000106432

M3 - Article

C2 - 17652956

SN - 1661-7800

VL - 93

SP - 1

EP - 6

JO - Neonatology

JF - Neonatology

IS - 1

ER -

Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia

Abstract

Keywords

Access to Document

Fingerprint

Cite this