Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes

Mirjam B. Smeets; Gerard Pasterkamp; Sai Kiang Lim; Evelyn Velema; Ben Van Middelaar; Dominique P.V. De Kleijn

doi:10.1016/S0014-5793(02)03343-4

Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes

Mirjam B. Smeets, Gerard Pasterkamp, Sai Kiang Lim, Evelyn Velema, Ben Van Middelaar, Dominique P.V. De Kleijn

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin-6 (IL-6). In the artery, shear stress and NO influence IL-6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL-6 levels. However, IL-6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression.

Original language	English
Pages (from-to)	221-224
Number of pages	4
Journal	FEBS letters
Volume	529
Issue number	2-3
DOIs	https://doi.org/10.1016/S0014-5793(02)03343-4
Publication status	Published - 9 Oct 2002

Keywords

Arterial remodeling
Flow change
Haptoglobin
Nitric oxide

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abstract = "The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin-6 (IL-6). In the artery, shear stress and NO influence IL-6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL-6 levels. However, IL-6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression.",

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AU - Smeets, Mirjam B.

AU - Pasterkamp, Gerard

AU - Lim, Sai Kiang

AU - Velema, Evelyn

AU - Van Middelaar, Ben

AU - De Kleijn, Dominique P.V.

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N2 - The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin-6 (IL-6). In the artery, shear stress and NO influence IL-6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL-6 levels. However, IL-6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression.

AB - The acute phase protein haptoglobin is highly expressed in arteries after sustained flow changes and involved in cell migration and arterial restructuring. In the liver, haptoglobin expression is mainly regulated by interleukin-6 (IL-6). In the artery, shear stress and NO influence IL-6 expression. In the present study, we demonstrate that NO synthesis is involved in the regulation of arterial haptoglobin expression after sustained flow changes. Decreased haptoglobin expression after NO inhibition coincided with decreased IL-6 levels. However, IL-6 knockout mice had normal arterial haptoglobin expression levels after sustained flow changes suggesting that other mediators may provide compensatory mechanisms for the regulation of arterial haptoglobin expression.

KW - Arterial remodeling

KW - Flow change

KW - Haptoglobin

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Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes

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