NFκB and MHC-1 Interplay in Neuroblastoma and Immunotherapy

Lotte Spel; Ariën Schiepers; Marianne Boes

doi:10.1016/j.trecan.2018.09.006

NFκB and MHC-1 Interplay in Neuroblastoma and Immunotherapy

Lotte Spel, Ariën Schiepers, Marianne Boes^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract

Pediatric neuroblastoma tumors are notorious nonimmunogenic cancers. In contrast to adult tumor types, neuroblastoma cells express low MHC-1, a derivative of its embryonic cell origin expressing little MHC-1. We here address the role of the nuclear factor kappa B (NFκB) pathway in controlling MHC-1 expression in embryonic neural crest cells, during differentiation of healthy cells, and in neuroblastoma tumors. Implications for immunotherapy are discussed.

Original language	English
Pages (from-to)	715-717
Number of pages	3
Journal	Trends in Cancer
Volume	4
Issue number	11
DOIs	https://doi.org/10.1016/j.trecan.2018.09.006
Publication status	Published - 1 Nov 2018

Keywords

immunotherapy
MHC-1
neural crest
neuroblastoma
nuclear factor kappa B

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10.1016/j.trecan.2018.09.006

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title = "NFκB and MHC-1 Interplay in Neuroblastoma and Immunotherapy",

abstract = "Pediatric neuroblastoma tumors are notorious nonimmunogenic cancers. In contrast to adult tumor types, neuroblastoma cells express low MHC-1, a derivative of its embryonic cell origin expressing little MHC-1. We here address the role of the nuclear factor kappa B (NFκB) pathway in controlling MHC-1 expression in embryonic neural crest cells, during differentiation of healthy cells, and in neuroblastoma tumors. Implications for immunotherapy are discussed.",

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AU - Spel, Lotte

AU - Schiepers, Ariën

AU - Boes, Marianne

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Y1 - 2018/11/1

N2 - Pediatric neuroblastoma tumors are notorious nonimmunogenic cancers. In contrast to adult tumor types, neuroblastoma cells express low MHC-1, a derivative of its embryonic cell origin expressing little MHC-1. We here address the role of the nuclear factor kappa B (NFκB) pathway in controlling MHC-1 expression in embryonic neural crest cells, during differentiation of healthy cells, and in neuroblastoma tumors. Implications for immunotherapy are discussed.

AB - Pediatric neuroblastoma tumors are notorious nonimmunogenic cancers. In contrast to adult tumor types, neuroblastoma cells express low MHC-1, a derivative of its embryonic cell origin expressing little MHC-1. We here address the role of the nuclear factor kappa B (NFκB) pathway in controlling MHC-1 expression in embryonic neural crest cells, during differentiation of healthy cells, and in neuroblastoma tumors. Implications for immunotherapy are discussed.

KW - immunotherapy

KW - MHC-1

KW - neural crest

KW - neuroblastoma

KW - nuclear factor kappa B

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U2 - 10.1016/j.trecan.2018.09.006

DO - 10.1016/j.trecan.2018.09.006

M3 - Short survey

C2 - 30352674

AN - SCOPUS:85054447822

SN - 2405-8033

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SP - 715

EP - 717

JO - Trends in Cancer

JF - Trends in Cancer

IS - 11

ER -

NFκB and MHC-1 Interplay in Neuroblastoma and Immunotherapy

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Keywords

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