TY - JOUR
T1 - New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases
AU - van Noorden, Cornelis J.F.
AU - Yetkin-Arik, Bahar
AU - Serrano Martinez, Paola
AU - Bakker, Noëlle
AU - van Breest Smallenburg, Mathilda E.
AU - Schlingemann, Reinier O.
AU - Klaassen, Ingeborg
AU - Majc, Bernarda
AU - Habic, Anamarija
AU - Bogataj, Urban
AU - Galun, S. Katrin
AU - Vittori, Milos
AU - Erdani Kreft, Mateja
AU - Novak, Metka
AU - Breznik, Barbara
AU - Hira, Vashendriya V.V.
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. (J Histochem Cytochem XX.XXX–XXX,
AB - Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk endothelial cells (ECs) also produce lactate and ATP by aerobic glycolysis. In fact, all proliferating cells, both non-cancer and cancer cells, need lactate for the biosynthesis of building blocks for cell growth and tissue expansion. Moreover, both non-proliferating cancer stem cells in tumors and leader tip ECs during angiogenesis rely on glycolysis for pyruvate production, which is used for ATP synthesis in mitochondria through oxidative phosphorylation (OXPHOS). Therefore, aerobic glycolysis is not a specific hallmark of cancer but rather a hallmark of proliferating cells and limits its utility in cancer therapy. However, local treatment of angiogenic eye conditions with inhibitors of glycolysis may be a safe therapeutic option that warrants experimental investigation. Most types of cells in the eye such as photoreceptors and pericytes use OXPHOS for ATP production, whereas proliferating angiogenic stalk ECs rely on glycolysis for lactate and ATP production. (J Histochem Cytochem XX.XXX–XXX,
KW - aerobic glycolysis
KW - anaerobic glycolysis
KW - angiogenesis
KW - ATP synthesis
KW - cancer cells
KW - cancer stem cells
KW - endothelial cells
KW - energy metabolism
KW - eye diseases
KW - oxidative phosphorylation
KW - pericytes
KW - retina
KW - Warburg effect
UR - http://www.scopus.com/inward/record.url?scp=85193562805&partnerID=8YFLogxK
U2 - 10.1369/00221554241249515
DO - 10.1369/00221554241249515
M3 - Review article
C2 - 38733294
AN - SCOPUS:85193562805
SN - 0022-1554
VL - 72
SP - 329
EP - 352
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
IS - 5
ER -