New antiarrhythmic targets to control intracellular calcium handling

H. Driessen; V.J.A. Bourgonje; T.A.B. van Veen; M.A. Vos

New antiarrhythmic targets to control intracellular calcium handling

H. Driessen, V.J.A. Bourgonje, T.A.B. van Veen, M.A. Vos

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Sudden cardiac death due to ventricular arrhythmias is a major problem. Drug therapies to prevent SCD do not provide satisfying results, leading to the demand for new antiarrhythmic strategies. New targets include Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII), the Na/Ca exchanger (NCX), the Ryanodine receptor (RyR, and its associated protein FKBP12.6 (Calstabin)) and the late component of the sodium current (I Na-Late ), all related to intracellular calcium (Ca(2+)) handling. In this review, drugs interfering with these targets (SEA-0400, K201, KN-93, W7, ranolazine, sophocarpine, and GS-967) are evaluated and their future as clinical compounds is considered. These new targets prove to be interesting; however more insight into long-term drug effects is necessary before clinical applicability becomes reality.

Original language	English
Pages (from-to)	198-213
Number of pages	16
Journal	Netherlands Heart Journal
Volume	22
Issue number	5
Publication status	Published - May 2014

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title = "New antiarrhythmic targets to control intracellular calcium handling",

abstract = "Sudden cardiac death due to ventricular arrhythmias is a major problem. Drug therapies to prevent SCD do not provide satisfying results, leading to the demand for new antiarrhythmic strategies. New targets include Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII), the Na/Ca exchanger (NCX), the Ryanodine receptor (RyR, and its associated protein FKBP12.6 (Calstabin)) and the late component of the sodium current (I Na-Late ), all related to intracellular calcium (Ca(2+)) handling. In this review, drugs interfering with these targets (SEA-0400, K201, KN-93, W7, ranolazine, sophocarpine, and GS-967) are evaluated and their future as clinical compounds is considered. These new targets prove to be interesting; however more insight into long-term drug effects is necessary before clinical applicability becomes reality. ",

author = "H. Driessen and V.J.A. Bourgonje and {van Veen}, T.A.B. and M.A. Vos",

year = "2014",

month = may,

language = "English",

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pages = "198--213",

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T1 - New antiarrhythmic targets to control intracellular calcium handling

AU - Driessen, H.

AU - Bourgonje, V.J.A.

AU - van Veen, T.A.B.

AU - Vos, M.A.

PY - 2014/5

Y1 - 2014/5

N2 - Sudden cardiac death due to ventricular arrhythmias is a major problem. Drug therapies to prevent SCD do not provide satisfying results, leading to the demand for new antiarrhythmic strategies. New targets include Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII), the Na/Ca exchanger (NCX), the Ryanodine receptor (RyR, and its associated protein FKBP12.6 (Calstabin)) and the late component of the sodium current (I Na-Late ), all related to intracellular calcium (Ca(2+)) handling. In this review, drugs interfering with these targets (SEA-0400, K201, KN-93, W7, ranolazine, sophocarpine, and GS-967) are evaluated and their future as clinical compounds is considered. These new targets prove to be interesting; however more insight into long-term drug effects is necessary before clinical applicability becomes reality.

AB - Sudden cardiac death due to ventricular arrhythmias is a major problem. Drug therapies to prevent SCD do not provide satisfying results, leading to the demand for new antiarrhythmic strategies. New targets include Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII), the Na/Ca exchanger (NCX), the Ryanodine receptor (RyR, and its associated protein FKBP12.6 (Calstabin)) and the late component of the sodium current (I Na-Late ), all related to intracellular calcium (Ca(2+)) handling. In this review, drugs interfering with these targets (SEA-0400, K201, KN-93, W7, ranolazine, sophocarpine, and GS-967) are evaluated and their future as clinical compounds is considered. These new targets prove to be interesting; however more insight into long-term drug effects is necessary before clinical applicability becomes reality.

M3 - Article

SN - 1568-5888

VL - 22

SP - 198

EP - 213

JO - Netherlands Heart Journal

JF - Netherlands Heart Journal

IS - 5

ER -

New antiarrhythmic targets to control intracellular calcium handling

Abstract

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