Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment: Kidney & blood pressure research

Mireille E. Emans; B. Braam; A. Diepenbroek; K. van der Putten; M. J. Cramer; J.P.M. Wielders; Dorine W. Swinkels; P. A. Doevendans; C. A. Gaillard

doi:10.1159/000343392

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment: Kidney & blood pressure research

Mireille E. Emans, B. Braam, A. Diepenbroek, K. van der Putten, M. J. Cramer, J.P.M. Wielders, Dorine W. Swinkels, P. A. Doevendans, C. A. Gaillard

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients. We investigated whether serum NGAL levels reflect iron metabolism in combined chronic heart failure and chronic kidney disease (CHF/CKD) and whether treatment with low-dose erythropoietin stimulating agent (ESA) modulates NGAL levels. Methods: In the EPOCARES trial (ClinTrialsNCT00356733) serum NGAL, hepcidin-25, transferrin saturation (TSAT), reticulocyte hemoglobin content (Ret-He) and endogenous erythropoietin (EPO) levels were measured. Results: Baseline serum NGAL levels correlated with cystatin C (r=0.767, p

Original language	English
Pages (from-to)	344-354
Number of pages	11
Journal	Kidney Blood Press Res
Volume	36
DOIs	https://doi.org/10.1159/000343392
Publication status	Published - 2012

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10.1159/000343392

http://www.ncbi.nlm.nih.gov/pubmed/23235391

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Emans, M. E., Braam, B., Diepenbroek, A., van der Putten, K., Cramer, M. J., Wielders, J. P. M., Swinkels, D. W., Doevendans, P. A., & Gaillard, C. A. (2012). Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment: Kidney & blood pressure research. Kidney Blood Press Res, 36, 344-354. https://doi.org/10.1159/000343392

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title = "Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment: Kidney & blood pressure research",

abstract = "Background: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients. We investigated whether serum NGAL levels reflect iron metabolism in combined chronic heart failure and chronic kidney disease (CHF/CKD) and whether treatment with low-dose erythropoietin stimulating agent (ESA) modulates NGAL levels. Methods: In the EPOCARES trial (ClinTrialsNCT00356733) serum NGAL, hepcidin-25, transferrin saturation (TSAT), reticulocyte hemoglobin content (Ret-He) and endogenous erythropoietin (EPO) levels were measured. Results: Baseline serum NGAL levels correlated with cystatin C (r=0.767, p",

author = "Emans, {Mireille E.} and B. Braam and A. Diepenbroek and {van der Putten}, K. and Cramer, {M. J.} and J.P.M. Wielders and Swinkels, {Dorine W.} and Doevendans, {P. A.} and Gaillard, {C. A.}",

note = "M1 - 1 Emans, Mireille E Braam, Branko Diepenbroek, Adry van der Putten, Karien Cramer, Maarten J Wielders, Jos P M Swinkels, Dorine W Doevendans, Pieter A Gaillard, Carlo A Kidney Blood Press Res. 2012 Dec 12;36(1):344-354.",

year = "2012",

doi = "10.1159/000343392",

language = "English",

volume = "36",

pages = "344--354",

}

Emans, ME, Braam, B, Diepenbroek, A, van der Putten, K, Cramer, MJ, Wielders, JPM, Swinkels, DW, Doevendans, PA & Gaillard, CA 2012, 'Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment: Kidney & blood pressure research', Kidney Blood Press Res, vol. 36, pp. 344-354. https://doi.org/10.1159/000343392

Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment: Kidney & blood pressure research. / Emans, Mireille E.; Braam, B.; Diepenbroek, A. et al.
In: Kidney Blood Press Res, Vol. 36, 2012, p. 344-354.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment

T2 - Kidney & blood pressure research

AU - Emans, Mireille E.

AU - Braam, B.

AU - Diepenbroek, A.

AU - van der Putten, K.

AU - Cramer, M. J.

AU - Wielders, J.P.M.

AU - Swinkels, Dorine W.

AU - Doevendans, P. A.

AU - Gaillard, C. A.

N1 - M1 - 1 Emans, Mireille E Braam, Branko Diepenbroek, Adry van der Putten, Karien Cramer, Maarten J Wielders, Jos P M Swinkels, Dorine W Doevendans, Pieter A Gaillard, Carlo A Kidney Blood Press Res. 2012 Dec 12;36(1):344-354.

PY - 2012

Y1 - 2012

N2 - Background: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients. We investigated whether serum NGAL levels reflect iron metabolism in combined chronic heart failure and chronic kidney disease (CHF/CKD) and whether treatment with low-dose erythropoietin stimulating agent (ESA) modulates NGAL levels. Methods: In the EPOCARES trial (ClinTrialsNCT00356733) serum NGAL, hepcidin-25, transferrin saturation (TSAT), reticulocyte hemoglobin content (Ret-He) and endogenous erythropoietin (EPO) levels were measured. Results: Baseline serum NGAL levels correlated with cystatin C (r=0.767, p

AB - Background: Neutrophil-gelatinase associated lipocalin (NGAL), a tubular injury marker, is associated with iron metabolism in hemodialysis patients. We investigated whether serum NGAL levels reflect iron metabolism in combined chronic heart failure and chronic kidney disease (CHF/CKD) and whether treatment with low-dose erythropoietin stimulating agent (ESA) modulates NGAL levels. Methods: In the EPOCARES trial (ClinTrialsNCT00356733) serum NGAL, hepcidin-25, transferrin saturation (TSAT), reticulocyte hemoglobin content (Ret-He) and endogenous erythropoietin (EPO) levels were measured. Results: Baseline serum NGAL levels correlated with cystatin C (r=0.767, p

U2 - 10.1159/000343392

DO - 10.1159/000343392

M3 - Article

SN - 1423-0143

VL - 36

SP - 344

EP - 354

JO - Kidney Blood Press Res

JF - Kidney Blood Press Res

ER -

Emans ME, Braam B, Diepenbroek A, van der Putten K, Cramer MJ, Wielders JPM et al. Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Chronic Cardiorenal Failure is Correlated with Endogenous Erythropoietin Levels and Decreases in Response to Low-Dose Erythropoietin Treatment: Kidney & blood pressure research. Kidney Blood Press Res. 2012;36:344-354. doi: 10.1159/000343392