Neutropenie door antistoffen tegen Fc-receptoren type III op neutrofiele granulocyten: 3 kinderen met verschillend ziektebeloop

Translated title of the contribution: Neutropenia due to antibodies against Type III Fc receptors on neutrophil granulocytes: 3 children with different clinical courses

V G Geukers, R H Veenhoven, A Y Schouten-van Meeteren, M C Bruin, M de Haas

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Three children (girls) suffered from neutropenia mediated by anti-neutrophil IgG-Fc receptor type III (Fc gamma RIII) antibodies. The first patient (newborn) had asymptomatic and transient neutropenia caused by maternal Fc gamma RIII iso-antibodies. The second patient (6 months), whose neutropenia was diagnosed as a 'benign neutropenia of childhood' caused by transient anti-NAI autoantibodies, suffered from mild bacterial infections. The third patient (12 years) suffered from serious infections. The anti-Fc gamma RIII autoantibodies showed neither anti-NA1 nor anti-NA2 specificity. She also developed autoimmune thyroiditis (Graves' disease). Both the duration of the neutropenia and the seriousness of the bacterial infection were variable in our patient group. The first two patients both made spontaneous recoveries, while the third patient depended ultimately on granulocyte-colony stimulating factor (G-CSF).

Translated title of the contributionNeutropenia due to antibodies against Type III Fc receptors on neutrophil granulocytes: 3 children with different clinical courses
Original languageDutch
Pages (from-to)362-4
Number of pages3
JournalNederlands Tijdschrift voor Geneeskunde
Volume142
Issue number7
Publication statusPublished - 14 Feb 1998

Keywords

  • Autoantibodies
  • Autoimmune Diseases
  • Bacterial Infections
  • Child
  • Female
  • Granulocyte Colony-Stimulating Factor
  • Humans
  • Infant
  • Infant, Newborn
  • Isoantibodies
  • Neutropenia
  • Neutrophils
  • Receptors, IgG

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