Neurological Disorders and Women's Health: Contribution of Molecular Neuroimaging Techniques

Ozgul Ekmekcioglu; Nathalie L Albert; Kathrin Heinrich; Nelleke Tolboom; Donatienne Van Weehaeghe; Tatiana Traub-Weidinger; Lutfiye Ozlem Atay; Valentina Garibotto; Silvia Morbelli

doi:10.1053/j.semnuclmed.2024.01.010

Neurological Disorders and Women's Health: Contribution of Molecular Neuroimaging Techniques

Ozgul Ekmekcioglu^*, Nathalie L Albert, Kathrin Heinrich, Nelleke Tolboom, Donatienne Van Weehaeghe, Tatiana Traub-Weidinger, Lutfiye Ozlem Atay, Valentina Garibotto, Silvia Morbelli

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Sex differences in brain physiology and the mechanisms of drug action have been extensively reported. These biological variances, from structure to hormonal and genetic aspects, can profoundly influence healthy functioning and disease mechanisms and might have implications for treatment and drug development. Molecular neuroimaging techniques may help to disclose sex's impact on brain functioning, as well as the neuropathological changes underpinning several diseases. This narrative review summarizes recent lines of evidence based on PET and SPECT imaging, highlighting sex differences in normal conditions and various neurological disorders.

Original language	English
Pages (from-to)	237-246
Number of pages	10
Journal	Seminars in nuclear medicine
Volume	54
Issue number	2
DOIs	https://doi.org/10.1053/j.semnuclmed.2024.01.010
Publication status	Published - Mar 2024

Keywords

Brain/diagnostic imaging
Female
Humans
Male
Nervous System Diseases/diagnostic imaging
Neuroimaging/methods
Tomography, Emission-Computed, Single-Photon
Women's Health

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10.1053/j.semnuclmed.2024.01.010

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title = "Neurological Disorders and Women's Health: Contribution of Molecular Neuroimaging Techniques",

abstract = "Sex differences in brain physiology and the mechanisms of drug action have been extensively reported. These biological variances, from structure to hormonal and genetic aspects, can profoundly influence healthy functioning and disease mechanisms and might have implications for treatment and drug development. Molecular neuroimaging techniques may help to disclose sex's impact on brain functioning, as well as the neuropathological changes underpinning several diseases. This narrative review summarizes recent lines of evidence based on PET and SPECT imaging, highlighting sex differences in normal conditions and various neurological disorders.",

keywords = "Brain/diagnostic imaging, Female, Humans, Male, Nervous System Diseases/diagnostic imaging, Neuroimaging/methods, Tomography, Emission-Computed, Single-Photon, Women's Health",

author = "Ozgul Ekmekcioglu and Albert, {Nathalie L} and Kathrin Heinrich and Nelleke Tolboom and {Van Weehaeghe}, Donatienne and Tatiana Traub-Weidinger and Atay, {Lutfiye Ozlem} and Valentina Garibotto and Silvia Morbelli",

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year = "2024",

month = mar,

doi = "10.1053/j.semnuclmed.2024.01.010",

language = "English",

volume = "54",

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T2 - Contribution of Molecular Neuroimaging Techniques

AU - Ekmekcioglu, Ozgul

AU - Albert, Nathalie L

AU - Heinrich, Kathrin

AU - Tolboom, Nelleke

AU - Van Weehaeghe, Donatienne

AU - Traub-Weidinger, Tatiana

AU - Atay, Lutfiye Ozlem

AU - Garibotto, Valentina

AU - Morbelli, Silvia

PY - 2024/3

Y1 - 2024/3

N2 - Sex differences in brain physiology and the mechanisms of drug action have been extensively reported. These biological variances, from structure to hormonal and genetic aspects, can profoundly influence healthy functioning and disease mechanisms and might have implications for treatment and drug development. Molecular neuroimaging techniques may help to disclose sex's impact on brain functioning, as well as the neuropathological changes underpinning several diseases. This narrative review summarizes recent lines of evidence based on PET and SPECT imaging, highlighting sex differences in normal conditions and various neurological disorders.

AB - Sex differences in brain physiology and the mechanisms of drug action have been extensively reported. These biological variances, from structure to hormonal and genetic aspects, can profoundly influence healthy functioning and disease mechanisms and might have implications for treatment and drug development. Molecular neuroimaging techniques may help to disclose sex's impact on brain functioning, as well as the neuropathological changes underpinning several diseases. This narrative review summarizes recent lines of evidence based on PET and SPECT imaging, highlighting sex differences in normal conditions and various neurological disorders.

KW - Brain/diagnostic imaging

KW - Female

KW - Humans

KW - Male

KW - Nervous System Diseases/diagnostic imaging

KW - Neuroimaging/methods

KW - Tomography, Emission-Computed, Single-Photon

KW - Women's Health

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U2 - 10.1053/j.semnuclmed.2024.01.010

DO - 10.1053/j.semnuclmed.2024.01.010

M3 - Review article

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SN - 0001-2998

VL - 54

SP - 237

EP - 246

JO - Seminars in nuclear medicine

JF - Seminars in nuclear medicine

IS - 2

ER -

Neurological Disorders and Women's Health: Contribution of Molecular Neuroimaging Techniques

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