TY - JOUR
T1 - Neuroimaging in the term newborn with neonatal encephalopathy
AU - Wisnowski, Jessica L
AU - Wintermark, Pia
AU - Bonifacio, Sonia L
AU - Smyser, Christopher D
AU - Barkovich, A James
AU - Edwards, A David
AU - de Vries, Linda S
AU - Inder, Terrie E
AU - Chau, Vann
N1 - Funding Information:
JLW is supported by grants from the National Institutes of Health ( K23HD099309 , U01NS092764 ). PW is supported by grants from FRSQ Clinical Research Scholar Career Award Senior and a Canadian Institutes of Health Research (CIHR) Project Grant.
Publisher Copyright:
© 2021
PY - 2021/10
Y1 - 2021/10
N2 - Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive biomarkers. Last, recommendations for neuroimaging in neonates with NE are presented.
AB - Neuroimaging is widely used to aid in the diagnosis and clinical management of neonates with neonatal encephalopathy (NE). Yet, despite widespread use clinically, there are few published guidelines on neuroimaging for neonates with NE. This review outlines the primary patterns of brain injury associated with hypoxic-ischemic injury in neonates with NE and their frequency, associated neuropathological features, and risk factors. In addition, it provides an overview of neuroimaging methods, including the most widely used scoring systems used to characterize brain injury in these neonates and their utility as predictive biomarkers. Last, recommendations for neuroimaging in neonates with NE are presented.
KW - Advanced MRI techniques
KW - Asphyxia
KW - Diffusion-tensor imaging
KW - Diffusion-weighted imaging
KW - Hypoxic-ischemic brain injury
KW - Magnetic resonance spectroscopy imaging
KW - Neonatal encephalopathy
KW - Neonates
KW - Outcome prediction
KW - Predictive values
UR - http://www.scopus.com/inward/record.url?scp=85119127186&partnerID=8YFLogxK
U2 - 10.1016/j.siny.2021.101304
DO - 10.1016/j.siny.2021.101304
M3 - Article
C2 - 34736808
SN - 1744-165X
VL - 26
SP - 1
EP - 13
JO - Seminars in Fetal & Neonatal Medicine
JF - Seminars in Fetal & Neonatal Medicine
IS - 5
M1 - 101304
ER -