TY - JOUR
T1 - Neural Substrates of Psychotic Depression
T2 - Findings From the Global ECT-MRI Research Collaboration
AU - Takamiya, Akihiro
AU - Dols, Annemiek
AU - Emsell, Louise
AU - Abbott, Christopher
AU - Yrondi, Antoine
AU - Soriano Mas, Carles
AU - Jorgensen, Martin Balslev
AU - Nordanskog, Pia
AU - Rhebergen, Didi
AU - van Exel, Eric
AU - Oudega, Mardien L
AU - Bouckaert, Filip
AU - Vandenbulcke, Mathieu
AU - Sienaert, Pascal
AU - Péran, Patrice
AU - Cano, Marta
AU - Cardoner, Narcis
AU - Jorgensen, Anders
AU - Paulson, Olaf B
AU - Hamilton, Paul
AU - Kampe, Robin
AU - Bruin, Willem
AU - Bartsch, Hauke
AU - Ousdal, Olga Therese
AU - Kessler, Ute
AU - van Wingen, Guido
AU - Oltedal, Leif
AU - Kishimoto, Taishiro
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.
AB - Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.
KW - Depression
KW - Gray matter volume
KW - Magnetic resonance imaging
KW - Medial prefrontal cortex
KW - Psychosis
UR - http://www.scopus.com/inward/record.url?scp=85125553668&partnerID=8YFLogxK
U2 - 10.1093/schbul/sbab122
DO - 10.1093/schbul/sbab122
M3 - Article
C2 - 34624103
SN - 0586-7614
VL - 48
SP - 514
EP - 523
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 2
ER -