Neural correlates of intolerance of uncertainty in clinical disorders

Mirjam Wever, Paul Smeets, Lot Sternheim*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Intolerance of uncertainty is a key contributor to anxiety-related disorders. Recent studies highlight its importance in other clinical disorders. The link between its clinical presentation and the underlying neural correlates remains unclear. This review summarizes the emerging literature on the neural correlates of intolerance of uncertainty. In conclusion, studies focusing on the neural correlates of this construct are sparse, and findings are inconsistent across disorders. Future research should identify neural correlates of intolerance of uncertainty in more detail. This may unravel the neurobiology of a wide variety of clinical disorders and pave the way for novel therapeutic targets.

Original languageEnglish
Pages (from-to)345-353
Number of pages9
JournalJournal of Neuropsychiatry and Clinical Neuroscience
Volume27
Issue number4
DOIs
Publication statusPublished - 1 Sept 2015

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