Neonatal disorders of germinal matrix

M M A Raets, J Dudink, P Govaert

Research output: Contribution to journalArticleAcademicpeer-review


The germinal matrix (GM) is a richly vascularized, transient layer near the ventricles. It produces neurons and glial cells, and is present in the foetal brain between 8 and 36 weeks of gestation. At 25 weeks, it reaches its maximum volume and subsequently withers. The GM is vulnerable to haemorrhage in preterm infants. This selective vulnerability is explained by limited astrocyte end-feet coverage of microvessels, reduced expression of fibronectin and immature tight junctions. Focal lesions in the neonatal period include haemorrhage, germinolysis and stroke. Such lesions in transient layers interrupt normal brain maturation and induce neurodevelopmental sequelae.

Original languageEnglish
Pages (from-to)2286-2290
Number of pages5
JournalJournal of Maternal-fetal & Neonatal Medicine
Issue numberSuppl 1
Publication statusPublished - Nov 2015


  • Germinal matrix
  • germinolysis
  • haemorrhage
  • neonatal


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