Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine

Bryan Van Den Broek; Jordy P.M. Coolen; Marien I. De Jonge; Ronald De Groot; Stefanie S.V. Henriet; Jeroen D. Langereis; Michiel Van Der Flier

doi:10.1097/INF.0000000000003259

Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine

Bryan Van Den Broek, Jordy P.M. Coolen, Marien I. De Jonge, Ronald De Groot, Stefanie S.V. Henriet, Jeroen D. Langereis, Michiel Van Der Flier^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.

Original language	English
Pages (from-to)	1019-1022
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	40
Issue number	11
DOIs	https://doi.org/10.1097/INF.0000000000003259
Publication status	Published - Nov 2021

Keywords

complement deficiency
immune compromised
MenB-4C
Neisseria meningitidis
vaccine

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10.1097/INF.0000000000003259

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Van Den Broek, B., Coolen, J. P. M., De Jonge, M. I., De Groot, R., Henriet, S. S. V., Langereis, J. D., & Van Der Flier, M. (2021). Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine. Pediatric Infectious Disease Journal, 40(11), 1019-1022. https://doi.org/10.1097/INF.0000000000003259

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title = "Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine",

abstract = "Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.",

keywords = "complement deficiency, immune compromised, MenB-4C, Neisseria meningitidis, vaccine",

author = "{Van Den Broek}, Bryan and Coolen, {Jordy P.M.} and {De Jonge}, {Marien I.} and {De Groot}, Ronald and Henriet, {Stefanie S.V.} and Langereis, {Jeroen D.} and {Van Der Flier}, Michiel",

year = "2021",

month = nov,

doi = "10.1097/INF.0000000000003259",

language = "English",

volume = "40",

pages = "1019--1022",

journal = "Pediatric Infectious Disease Journal",

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Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine. / Van Den Broek, Bryan; Coolen, Jordy P.M.; De Jonge, Marien I. et al.
In: Pediatric Infectious Disease Journal, Vol. 40, No. 11, 11.2021, p. 1019-1022.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine

AU - Van Den Broek, Bryan

AU - Coolen, Jordy P.M.

AU - De Jonge, Marien I.

AU - De Groot, Ronald

AU - Henriet, Stefanie S.V.

AU - Langereis, Jeroen D.

AU - Van Der Flier, Michiel

PY - 2021/11

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AB - Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.

KW - complement deficiency

KW - immune compromised

KW - MenB-4C

KW - Neisseria meningitidis

KW - vaccine

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Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine

Abstract

Keywords

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