Near Full-Length Characterization and Population Dynamics of the Human Immunodeficiency Virus Type I Circulating Recombinant Form 42 (CRF42_BF) in Luxembourg

Daniel Struck*, Francois Roman, Sebastien De Landtsheer, Jean-Yves Servais, Christine Lambert, Cecile Masquelier, Veronique Venard, Jean Ruelle, Monique Nijhuis, Jean-Claude Schmit, Carole Seguin-Devaux

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A new recombinant form representing a mosaic of HIV-1 subtype B and F1 and designated as CRF42_BF was identified in Luxembourg. We confirmed the inedited nature of CRF42_BF by near full-length genome characterization and retrieved a possible ancestor originating from Brazil. The demographic history of CRF42_BF in Luxembourg using Bayesian coalescent-based methods was investigated. The exponential phase of the logistic growth happened in a very short time period of approximately 5 months associated with a high mean rate of population growth of 15.02 new infections per year. However, CRF42_BF was not characterized by either a higher ex vivo replication capacity in peripheral blood mononuclear cells (PBMCs) or a higher ex vivo transmission efficiency from monocyte-derived dendritic cells to PBMCs as compared to B and F1 viruses. These data do not support a high pathogenic potential of CFR42_BF but rather an initial bursting spread of the recombinant probably due to a more favorable transmission route.

Original languageEnglish
Pages (from-to)554-558
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume31
Issue number5
DOIs
Publication statusPublished - 1 May 2015

Keywords

  • HIV-1 SUBTYPE-B

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