Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project

Rob Beelen; Gerard Hoek; Ole Raaschou-Nielsen; Massimo Stafoggia; Zorana Jovanovic Andersen; Gudrun Weinmayr; Barbara Hoffmann; Kathrin Wolf; Evangelia Samoli; Paul H. Fischer; Mark J. Nieuwenhuijsen; Wei W. Xun; Klea Katsouyanni; Konstantina Dimakopoulou; Alessandro Marcon; Erkki Vartiainen; Timo Lanki; Tarja Yli-Tuomi; Bente Oftedal; Per E. Schwarze; Per Nafstad; Ulf de Faire; Nancy L. Pedersen; Claes Göran Östenson; Laura Fratiglioni; Johanna Penell; Michal Korek; Göran Pershagen; Kirsten Thorup Eriksen; Kim Overvad; Mette Sørensen; Marloes Eeftens; Petra H. Peeters; Kees Meliefste; Meng Wang; H. Bas Bueno-De-Mesquita; Dorothea Sugiri; Ursula Krämer; Joachim Heinrich; Kees De Hoogh; Timothy Key; Annette Peters; Regina Hampel; Hans Concin; Gabriele Nagel; Andrea Jaensch; Alex Ineichen; Ming Yi Tsai; Emmanuel Schaffner; Nicole M. Probst-Hensch; Christian Schindler; Martina S. Ragettli; Alice Vilier; Françoise Clavel-Chapelon; Christophe Declercq; Fulvio Ricceri; Carlotta Sacerdote; Claudia Galassi; Enrica Migliore; Andrea Ranzi; Giulia Cesaroni; Chiara Badaloni; Francesco Forastiere; Michail Katsoulis; Antonia Trichopoulou; Menno Keuken; Aleksandra Jedynska; Ingeborg M. Kooter; Jaakko Kukkonen; Ranjeet S. Sokhi; Paolo Vineis; Bert Brunekreef

doi:10.1289/ehp.1408095

Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project

Rob Beelen^*, Gerard Hoek, Ole Raaschou-Nielsen, Massimo Stafoggia, Zorana Jovanovic Andersen, Gudrun Weinmayr, Barbara Hoffmann, Kathrin Wolf, Evangelia Samoli, Paul H. Fischer, Mark J. Nieuwenhuijsen, Wei W. Xun, Klea Katsouyanni, Konstantina Dimakopoulou, Alessandro Marcon, Erkki Vartiainen, Timo Lanki, Tarja Yli-Tuomi, Bente Oftedal, Per E. SchwarzePer Nafstad, Ulf de Faire, Nancy L. Pedersen, Claes Göran Östenson, Laura Fratiglioni, Johanna Penell, Michal Korek, Göran Pershagen, Kirsten Thorup Eriksen, Kim Overvad, Mette Sørensen, Marloes Eeftens, Petra H. Peeters, Kees Meliefste, Meng Wang, H. Bas Bueno-De-Mesquita, Dorothea Sugiri, Ursula Krämer, Joachim Heinrich, Kees De Hoogh, Timothy Key, Annette Peters, Regina Hampel, Hans Concin, Gabriele Nagel, Andrea Jaensch, Alex Ineichen, Ming Yi Tsai, Emmanuel Schaffner, Nicole M. Probst-Hensch, Christian Schindler, Martina S. Ragettli, Alice Vilier, Françoise Clavel-Chapelon, Christophe Declercq, Fulvio Ricceri, Carlotta Sacerdote, Claudia Galassi, Enrica Migliore, Andrea Ranzi, Giulia Cesaroni, Chiara Badaloni, Francesco Forastiere, Michail Katsoulis, Antonia Trichopoulou, Menno Keuken, Aleksandra Jedynska, Ingeborg M. Kooter, Jaakko Kukkonen, Ranjeet S. Sokhi, Paolo Vineis, Bert Brunekreef

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM<inf>2.5</inf>) and ≤ 10 μm (PM<inf>10</inf>) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM<inf>2.5</inf> sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m<sup>3</sup>). In a two-pollutant model, the association with PM<inf>2.5</inf> sulfur was robust to adjustment for PM<inf>2.5</inf> mass, whereas the association with PM<inf>2.5</inf> mass was reduced. conclusions: Long-term exposure to PM<inf>2.5</inf> sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM<inf>2.5</inf>.

Original language	English
Pages (from-to)	525-533
Number of pages	9
Journal	Environmental Health Perspectives
Volume	123
Issue number	6
DOIs	https://doi.org/10.1289/ehp.1408095
Publication status	Published - 2015

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Beelen, R., Hoek, G., Raaschou-Nielsen, O., Stafoggia, M., Andersen, Z. J., Weinmayr, G., Hoffmann, B., Wolf, K., Samoli, E., Fischer, P. H., Nieuwenhuijsen, M. J., Xun, W. W., Katsouyanni, K., Dimakopoulou, K., Marcon, A., Vartiainen, E., Lanki, T., Yli-Tuomi, T., Oftedal, B., ... Brunekreef, B. (2015). Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project. Environmental Health Perspectives, 123(6), 525-533. https://doi.org/10.1289/ehp.1408095

@article{e7efc1403af64cedafa111d3b62975e0,

title = "Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project",

abstract = "Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. conclusions: Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5.",

author = "Rob Beelen and Gerard Hoek and Ole Raaschou-Nielsen and Massimo Stafoggia and Andersen, {Zorana Jovanovic} and Gudrun Weinmayr and Barbara Hoffmann and Kathrin Wolf and Evangelia Samoli and Fischer, {Paul H.} and Nieuwenhuijsen, {Mark J.} and Xun, {Wei W.} and Klea Katsouyanni and Konstantina Dimakopoulou and Alessandro Marcon and Erkki Vartiainen and Timo Lanki and Tarja Yli-Tuomi and Bente Oftedal and Schwarze, {Per E.} and Per Nafstad and {de Faire}, Ulf and Pedersen, {Nancy L.} and {\"O}stenson, {Claes G{\"o}ran} and Laura Fratiglioni and Johanna Penell and Michal Korek and G{\"o}ran Pershagen and Eriksen, {Kirsten Thorup} and Kim Overvad and Mette S{\o}rensen and Marloes Eeftens and Peeters, {Petra H.} and Kees Meliefste and Meng Wang and {Bas Bueno-De-Mesquita}, H. and Dorothea Sugiri and Ursula Kr{\"a}mer and Joachim Heinrich and {De Hoogh}, Kees and Timothy Key and Annette Peters and Regina Hampel and Hans Concin and Gabriele Nagel and Andrea Jaensch and Alex Ineichen and Tsai, {Ming Yi} and Emmanuel Schaffner and Probst-Hensch, {Nicole M.} and Christian Schindler and Ragettli, {Martina S.} and Alice Vilier and Fran{\c c}oise Clavel-Chapelon and Christophe Declercq and Fulvio Ricceri and Carlotta Sacerdote and Claudia Galassi and Enrica Migliore and Andrea Ranzi and Giulia Cesaroni and Chiara Badaloni and Francesco Forastiere and Michail Katsoulis and Antonia Trichopoulou and Menno Keuken and Aleksandra Jedynska and Kooter, {Ingeborg M.} and Jaakko Kukkonen and Sokhi, {Ranjeet S.} and Paolo Vineis and Bert Brunekreef",

year = "2015",

doi = "10.1289/ehp.1408095",

language = "English",

volume = "123",

pages = "525--533",

journal = "Environmental Health Perspectives",

issn = "0091-6765",

publisher = "Public Health Services, US Dept of Health and Human Services",

number = "6",

}

Beelen, R, Hoek, G, Raaschou-Nielsen, O, Stafoggia, M, Andersen, ZJ, Weinmayr, G, Hoffmann, B, Wolf, K, Samoli, E, Fischer, PH, Nieuwenhuijsen, MJ, Xun, WW, Katsouyanni, K, Dimakopoulou, K, Marcon, A, Vartiainen, E, Lanki, T, Yli-Tuomi, T, Oftedal, B, Schwarze, PE, Nafstad, P, de Faire, U, Pedersen, NL, Östenson, CG, Fratiglioni, L, Penell, J, Korek, M, Pershagen, G, Eriksen, KT, Overvad, K, Sørensen, M, Eeftens, M, Peeters, PH, Meliefste, K, Wang, M, Bas Bueno-De-Mesquita, H, Sugiri, D, Krämer, U, Heinrich, J, De Hoogh, K, Key, T, Peters, A, Hampel, R, Concin, H, Nagel, G, Jaensch, A, Ineichen, A, Tsai, MY, Schaffner, E, Probst-Hensch, NM, Schindler, C, Ragettli, MS, Vilier, A, Clavel-Chapelon, F, Declercq, C, Ricceri, F, Sacerdote, C, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Katsoulis, M, Trichopoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Sokhi, RS, Vineis, P & Brunekreef, B 2015, 'Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project', Environmental Health Perspectives, vol. 123, no. 6, pp. 525-533. https://doi.org/10.1289/ehp.1408095

TY - JOUR

T1 - Natural-cause mortality and long-term exposure to particle components

T2 - An Analysis of 19 European cohorts within the multi-center ESCAPE project

AU - Beelen, Rob

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

AU - Stafoggia, Massimo

AU - Andersen, Zorana Jovanovic

AU - Weinmayr, Gudrun

AU - Hoffmann, Barbara

AU - Wolf, Kathrin

AU - Samoli, Evangelia

AU - Fischer, Paul H.

AU - Nieuwenhuijsen, Mark J.

AU - Xun, Wei W.

AU - Katsouyanni, Klea

AU - Dimakopoulou, Konstantina

AU - Marcon, Alessandro

AU - Vartiainen, Erkki

AU - Lanki, Timo

AU - Yli-Tuomi, Tarja

AU - Oftedal, Bente

AU - Schwarze, Per E.

AU - Nafstad, Per

AU - de Faire, Ulf

AU - Pedersen, Nancy L.

AU - Östenson, Claes Göran

AU - Fratiglioni, Laura

AU - Penell, Johanna

AU - Korek, Michal

AU - Pershagen, Göran

AU - Eriksen, Kirsten Thorup

AU - Overvad, Kim

AU - Sørensen, Mette

AU - Eeftens, Marloes

AU - Peeters, Petra H.

AU - Meliefste, Kees

AU - Wang, Meng

AU - Bas Bueno-De-Mesquita, H.

AU - Sugiri, Dorothea

AU - Krämer, Ursula

AU - Heinrich, Joachim

AU - De Hoogh, Kees

AU - Key, Timothy

AU - Peters, Annette

AU - Hampel, Regina

AU - Concin, Hans

AU - Nagel, Gabriele

AU - Jaensch, Andrea

AU - Ineichen, Alex

AU - Tsai, Ming Yi

AU - Schaffner, Emmanuel

AU - Probst-Hensch, Nicole M.

AU - Schindler, Christian

AU - Ragettli, Martina S.

AU - Vilier, Alice

AU - Clavel-Chapelon, Françoise

AU - Declercq, Christophe

AU - Ricceri, Fulvio

AU - Sacerdote, Carlotta

AU - Galassi, Claudia

AU - Migliore, Enrica

AU - Ranzi, Andrea

AU - Cesaroni, Giulia

AU - Badaloni, Chiara

AU - Forastiere, Francesco

AU - Katsoulis, Michail

AU - Trichopoulou, Antonia

AU - Keuken, Menno

AU - Jedynska, Aleksandra

AU - Kooter, Ingeborg M.

AU - Kukkonen, Jaakko

AU - Sokhi, Ranjeet S.

AU - Vineis, Paolo

AU - Brunekreef, Bert

PY - 2015

Y1 - 2015

N2 - Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. conclusions: Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5.

AB - Background: Studies have shown associations between mortality and long-term exposure to particulate matter air pollution. Few cohort studies have estimated the effects of the elemental composition of particulate matter on mortality. oBjectives: Our aim was to study the association between natural-cause mortality and long-term exposure to elemental components of particulate matter. Methods: Mortality and confounder data from 19 European cohort studies were used. Residential exposure to eight a priori–selected components of particulate matter (PM) was characterized following a strictly standardized protocol. Annual average concentrations of copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc within PM size fractions ≤ 2.5 μm (PM2.5) and ≤ 10 μm (PM10) were estimated using land-use regression models. Cohort-specific statistical analyses of the associations between mortality and air pollution were conducted using Cox proportional hazards models using a common protocol followed by meta-analysis. results: The total study population consisted of 291,816 participants, of whom 25,466 died from a natural cause during follow-up (average time of follow-up, 14.3 years). Hazard ratios were positive for almost all elements and statistically significant for PM2.5 sulfur (1.14; 95% CI: 1.06, 1.23 per 200 ng/m3). In a two-pollutant model, the association with PM2.5 sulfur was robust to adjustment for PM2.5 mass, whereas the association with PM2.5 mass was reduced. conclusions: Long-term exposure to PM2.5 sulfur was associated with natural-cause mortality. This association was robust to adjustment for other pollutants and PM2.5.

UR - http://www.scopus.com/inward/record.url?scp=84930532752&partnerID=8YFLogxK

U2 - 10.1289/ehp.1408095

DO - 10.1289/ehp.1408095

M3 - Article

C2 - 25712504

AN - SCOPUS:84930532752

SN - 0091-6765

VL - 123

SP - 525

EP - 533

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

IS - 6

ER -

Natural-cause mortality and long-term exposure to particle components: An Analysis of 19 European cohorts within the multi-center ESCAPE project

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