TY - JOUR
T1 - Native T1 reference values for nonischemic cardiomyopathies and populations with increased cardiovascular risk
T2 - A systematic review and meta-analysis
AU - van den Boomen, Maaike
AU - Slart, Riemer H.J.A.
AU - Hulleman, Enzo V.
AU - Dierckx, Rudi A.J.O.
AU - Velthuis, Birgitta K.
AU - van der Harst, Pim
AU - Sosnovik, David E.
AU - Borra, Ronald J.H.
AU - Prakken, Niek H.J.
N1 - Funding Information:
Nonischemic cardiomyopathy (NICM) is a prevalent disease characterized by different patterns of fibrosis in the myocardium that can eventually cause heart failure. According to the American Heart Association (AHA) and the National Institutes of Health (NIH), NICM comprises a heterogeneous group of cardiac diseases presenting as: hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), or restrictive cardiomyopathy (RCM).1 HCM alone affects 1/500 adults2 and its prevalence increases with age. Other populations also have an increased risk of developing NICM according to the AHA. These include the one-third of the USA population that has high blood pressure,3 the approximately one-tenth that suffers from diabetes4; and the two-thirds that are either overweight (body mass index [BMI] ≥25) or obese (BMI ≥30).5,6
Publisher Copyright:
© 2017 The Authors Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Background: Although cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory. Purpose: To determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk. Study Type: Systemic review and meta-analysis. Population: Patients with NICM, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), and patients with myocarditis (MC), iron overload, amyloidosis, Fabry disease, and populations with hypertension (HT), diabetes mellitus (DM), and obesity. Field Strength/Sequence: (Shortened) modified Look–Locker inversion-recovery MR sequence at 1.5 or 3T. Assessment: PubMed and Embase were searched following the PRISMA guidelines. Statistical Tests: The summary of standard mean difference (SMD) between the diseased and a healthy control populations was generated using a random-effects model in combination with meta-regression analysis. Results: The SMD for HCM, DCM, and MC patients were significantly increased (1.41, 1.48, and 1.96, respectively, P < 0.01) compared with healthy controls. The SMD for HT patients with and without left-ventricle hypertrophy (LVH) together was significantly increased (0.19, P = 0.04), while for HT patients without LVH the SMD was zero (0.03, P = 0.52). The number of studies on amyloidosis, iron overload, Fabry disease, and HT patients with LVH did not meet the requirement to perform a meta-analysis. However, most studies reported a significantly increased T1 for amyloidosis and HT patients with LVH and a significant decreased T1 for iron overload and Fabry disease patients. Data Conclusions: Native T1 mapping by using an (Sh)MOLLI sequence can potentially assess myocardial changes in HCM, DCM, MC, iron overload, amyloidosis, and Fabry disease compared to controls. In addition, it can help to diagnose left-ventricular remodeling in HT patients. Level of Evidence: 2. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018;47:891–912.
AB - Background: Although cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory. Purpose: To determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk. Study Type: Systemic review and meta-analysis. Population: Patients with NICM, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), and patients with myocarditis (MC), iron overload, amyloidosis, Fabry disease, and populations with hypertension (HT), diabetes mellitus (DM), and obesity. Field Strength/Sequence: (Shortened) modified Look–Locker inversion-recovery MR sequence at 1.5 or 3T. Assessment: PubMed and Embase were searched following the PRISMA guidelines. Statistical Tests: The summary of standard mean difference (SMD) between the diseased and a healthy control populations was generated using a random-effects model in combination with meta-regression analysis. Results: The SMD for HCM, DCM, and MC patients were significantly increased (1.41, 1.48, and 1.96, respectively, P < 0.01) compared with healthy controls. The SMD for HT patients with and without left-ventricle hypertrophy (LVH) together was significantly increased (0.19, P = 0.04), while for HT patients without LVH the SMD was zero (0.03, P = 0.52). The number of studies on amyloidosis, iron overload, Fabry disease, and HT patients with LVH did not meet the requirement to perform a meta-analysis. However, most studies reported a significantly increased T1 for amyloidosis and HT patients with LVH and a significant decreased T1 for iron overload and Fabry disease patients. Data Conclusions: Native T1 mapping by using an (Sh)MOLLI sequence can potentially assess myocardial changes in HCM, DCM, MC, iron overload, amyloidosis, and Fabry disease compared to controls. In addition, it can help to diagnose left-ventricular remodeling in HT patients. Level of Evidence: 2. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018;47:891–912.
KW - (Sh)MOLLI
KW - cardiac risk populations
KW - diffuse fibrosis
KW - meta-analysis
KW - native T mapping
KW - nonischemic cardiomyopathy
UR - http://www.scopus.com/inward/record.url?scp=85043576689&partnerID=8YFLogxK
U2 - 10.1002/jmri.25885
DO - 10.1002/jmri.25885
M3 - Review article
C2 - 29131444
AN - SCOPUS:85043576689
SN - 1053-1807
VL - 47
SP - 891
EP - 912
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 4
ER -