National Protocol for Model-Based Selection for Proton Therapy in Head and Neck Cancer

Johannes A Langendijk, Frank J P Hoebers, Martin A de Jong, Patricia Doornaert, Chris H J Terhaard, Roel J H M Steenbakkers, Olga Hamming-Vrieze, Jeroen B van de Kamer, Wilko F A R Verbakel, Fatma Keskin-Cambay, Johannes B Reitsma, Arjen van der Schaaf, Liesbeth J Boersma, Ewoud Schuit

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In the Netherlands, the model-based approach is used to identify patients with head and neck cancer who may benefit most from proton therapy in terms of prevention of late radiation-induced side effects in comparison with photon therapy. To this purpose, a National Indication Protocol Proton therapy for Head and Neck Cancer patients (NIPP-HNC) was developed, which has been approved by the health care authorities. When patients qualify according to the guidelines of the NIPP-HNC, proton therapy is fully reimbursed. This article describes the procedures that were followed to develop this NIPP-HNC and provides all necessary information to introduce model-based selection for patients with head and neck cancer into routine clinical practice.

Original languageEnglish
Pages (from-to)354-365
Number of pages12
JournalInternational journal of particle therapy
Issue number1
Publication statusPublished - 1 Jun 2021


  • head and neck cancer
  • model-based selection
  • national indication protocol
  • proton therapy
  • radiation-induced side effects
  • Radiation-induced side effects
  • Model-based selection
  • National indication protocol
  • Head and neck cancer
  • Proton therapy


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