@article{250facaed3e54c2186a23f58f946f0e7,
title = "Nasopharyngeal carcinoma in children and adolescents: The EXPeRT/PARTNER diagnostic and therapeutic recommendations",
abstract = "Nasopharyngeal carcinoma (NPC) is a rare pediatric tumor. Collaborative studies performed over the last decades showed improved results compared to historical data, but standardized guidelines for diagnosis and management of pediatric NPC are still unavailable. This study presents a European consensus guideline for the diagnosis and treatment of pediatric NPC developed by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT). Main recommendations include induction chemotherapy with cisplatin and 5-flurouracil, concomitant chemoradiotherapy in advanced disease, and to consider maintenance treatment with interferon beta (IFN-β) for selected high-risk patients. Dose adjustments of radiotherapy based on response to induction chemotherapy may decrease the rates of long-term treatment-related complications that affect most of the survivors.",
keywords = "adolescent, children, nasopharyngeal carcinoma, radiotherapy, rare tumors, recommendations",
author = "Tal Ben-Ami and Udo Kontny and Aurore Surun and Brecht, {Ines B.} and Almaraz, {Ricardo L{\'o}pez} and Monica Dragomir and Apostolos Pourtsidis and Michela Casanova and Brice Fresneau and Gianni Bisogno and Schneider, {Dominik T.} and Yves Reguerre and Ewa Bien and Teresa Stachowicz-Stencel and Gustaf {\"O}sterlundh and Marc Wygoda and Janssens, {Geert O.} and J{\'o}zsef Zsiros and Nina Jehanno and Brisse, {Herve J.} and Lorenza Gandola and Hans Christiansen and Line Claude and Andrea Ferrari and Carlos Rodriguez-Galindo and Daniel Orbach",
note = "Funding Information: The authors have no financial relationships relevant to this article to disclose. The French FRACTURE group is supported by “SFCE ‐ Enfants Cancers et Sant{\'e}.” The German STEP Registry is supported by the German Childhood Cancer Foundation. The Italian TREP Registry has been partially supported by Fondazione Giovanni Celeghin, ONLUS. Funding Information: This publication is part of the EU PARTNER project (ERN‐PAEDCAN Partner Paediatric Rare Tumours Network ‐ European Registry), which has received funding from the European Union's Health Programme (2014–2020) (third Health Programme Call: HP‐PJ‐06‐2016: Rare diseases ‐ support for New Registries; CHAFEA Grant Number: 777336). Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC {\textcopyright} 2021 Wiley Periodicals LLC.",
year = "2021",
month = jun,
doi = "10.1002/pbc.29018",
language = "English",
volume = "68 Suppl 4",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "S4",
}