Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

I M Leonie Majoie; J Marja Oldhoff; Huib van Weelden; Marloes Laaper-Ertmann; Mente T Bousema; Vigfus Sigurdsson; Edward F Knol; Carla A F Bruijnzeel-Koomen; Marjolein S de Bruin-Weller

doi:10.1016/j.jaad.2008.08.048

Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

I M Leonie Majoie, J Marja Oldhoff, Huib van Weelden, Marloes Laaper-Ertmann, Mente T Bousema, Vigfus Sigurdsson, Edward F Knol, Carla A F Bruijnzeel-Koomen, Marjolein S de Bruin-Weller

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD.

OBJECTIVES: We sought to compare the clinical and immunohistochemical effects of narrowband (NB) UVB and MD UVA1 treatment in patients with AD.

METHODS: Thirteen adult patients with AD were included in this randomized investigator-blinded half-sided comparison study between NB UVB and MD UVA1. Disease activity was measured using the Leicester sign score. Skin biopsy specimens were taken before and after phototherapy. Regulatory T cells were stained with the forkhead box protein P3 (FoxP3).

RESULTS: NB UVB and MD UVA1 both significantly decreased AD severity (P < .01) and the dermal cellular infiltrate. The percentage of FoxP3(+)CD3(+) T cells did not change after NB UVB or MD UVA1 treatment.

LIMITATION: MD UVA1 therapy was given 3 times per week instead of the preferred regimen of 5 times per week. This was necessary to achieve good blinding of the study.

CONCLUSIONS: NB UVB and MD UVA1 seem equally effective in the treatment of patients with moderate to severe AD. Neither MD UVA1 nor NB UVB had an effect on the percentage of FoxP3(+)CD3(+) T cells.

Original language	English
Pages (from-to)	77-84
Number of pages	8
Journal	Journal of the American Academy of Dermatology
Volume	60
Issue number	1
DOIs	https://doi.org/10.1016/j.jaad.2008.08.048
Publication status	Published - Jan 2009

Keywords

Adult
Dermatitis, Atopic
Female
Humans
Immunohistochemistry
Male
Middle Aged
Severity of Illness Index
Single-Blind Method
Ultraviolet Therapy
Young Adult

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10.1016/j.jaad.2008.08.048

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Majoie, I. M. L., Oldhoff, J. M., van Weelden, H., Laaper-Ertmann, M., Bousema, M. T., Sigurdsson, V., Knol, E. F., Bruijnzeel-Koomen, C. A. F., & de Bruin-Weller, M. S. (2009). Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis. Journal of the American Academy of Dermatology, 60(1), 77-84. https://doi.org/10.1016/j.jaad.2008.08.048

@article{b31b903366194872b15d16c80d0c837f,

title = "Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis",

abstract = "BACKGROUND: Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD.OBJECTIVES: We sought to compare the clinical and immunohistochemical effects of narrowband (NB) UVB and MD UVA1 treatment in patients with AD.METHODS: Thirteen adult patients with AD were included in this randomized investigator-blinded half-sided comparison study between NB UVB and MD UVA1. Disease activity was measured using the Leicester sign score. Skin biopsy specimens were taken before and after phototherapy. Regulatory T cells were stained with the forkhead box protein P3 (FoxP3).RESULTS: NB UVB and MD UVA1 both significantly decreased AD severity (P < .01) and the dermal cellular infiltrate. The percentage of FoxP3(+)CD3(+) T cells did not change after NB UVB or MD UVA1 treatment.LIMITATION: MD UVA1 therapy was given 3 times per week instead of the preferred regimen of 5 times per week. This was necessary to achieve good blinding of the study.CONCLUSIONS: NB UVB and MD UVA1 seem equally effective in the treatment of patients with moderate to severe AD. Neither MD UVA1 nor NB UVB had an effect on the percentage of FoxP3(+)CD3(+) T cells.",

keywords = "Adult, Dermatitis, Atopic, Female, Humans, Immunohistochemistry, Male, Middle Aged, Severity of Illness Index, Single-Blind Method, Ultraviolet Therapy, Young Adult",

author = "Majoie, {I M Leonie} and Oldhoff, {J Marja} and {van Weelden}, Huib and Marloes Laaper-Ertmann and Bousema, {Mente T} and Vigfus Sigurdsson and Knol, {Edward F} and Bruijnzeel-Koomen, {Carla A F} and {de Bruin-Weller}, {Marjolein S}",

year = "2009",

month = jan,

doi = "10.1016/j.jaad.2008.08.048",

language = "English",

volume = "60",

pages = "77--84",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Mosby Inc.",

number = "1",

}

Majoie, IML, Oldhoff, JM, van Weelden, H, Laaper-Ertmann, M, Bousema, MT, Sigurdsson, V, Knol, EF, Bruijnzeel-Koomen, CAF & de Bruin-Weller, MS 2009, 'Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis', Journal of the American Academy of Dermatology, vol. 60, no. 1, pp. 77-84. https://doi.org/10.1016/j.jaad.2008.08.048

TY - JOUR

T1 - Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

AU - Majoie, I M Leonie

AU - Oldhoff, J Marja

AU - van Weelden, Huib

AU - Laaper-Ertmann, Marloes

AU - Bousema, Mente T

AU - Sigurdsson, Vigfus

AU - Knol, Edward F

AU - Bruijnzeel-Koomen, Carla A F

AU - de Bruin-Weller, Marjolein S

PY - 2009/1

Y1 - 2009/1

N2 - BACKGROUND: Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD.OBJECTIVES: We sought to compare the clinical and immunohistochemical effects of narrowband (NB) UVB and MD UVA1 treatment in patients with AD.METHODS: Thirteen adult patients with AD were included in this randomized investigator-blinded half-sided comparison study between NB UVB and MD UVA1. Disease activity was measured using the Leicester sign score. Skin biopsy specimens were taken before and after phototherapy. Regulatory T cells were stained with the forkhead box protein P3 (FoxP3).RESULTS: NB UVB and MD UVA1 both significantly decreased AD severity (P < .01) and the dermal cellular infiltrate. The percentage of FoxP3(+)CD3(+) T cells did not change after NB UVB or MD UVA1 treatment.LIMITATION: MD UVA1 therapy was given 3 times per week instead of the preferred regimen of 5 times per week. This was necessary to achieve good blinding of the study.CONCLUSIONS: NB UVB and MD UVA1 seem equally effective in the treatment of patients with moderate to severe AD. Neither MD UVA1 nor NB UVB had an effect on the percentage of FoxP3(+)CD3(+) T cells.

AB - BACKGROUND: Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD.OBJECTIVES: We sought to compare the clinical and immunohistochemical effects of narrowband (NB) UVB and MD UVA1 treatment in patients with AD.METHODS: Thirteen adult patients with AD were included in this randomized investigator-blinded half-sided comparison study between NB UVB and MD UVA1. Disease activity was measured using the Leicester sign score. Skin biopsy specimens were taken before and after phototherapy. Regulatory T cells were stained with the forkhead box protein P3 (FoxP3).RESULTS: NB UVB and MD UVA1 both significantly decreased AD severity (P < .01) and the dermal cellular infiltrate. The percentage of FoxP3(+)CD3(+) T cells did not change after NB UVB or MD UVA1 treatment.LIMITATION: MD UVA1 therapy was given 3 times per week instead of the preferred regimen of 5 times per week. This was necessary to achieve good blinding of the study.CONCLUSIONS: NB UVB and MD UVA1 seem equally effective in the treatment of patients with moderate to severe AD. Neither MD UVA1 nor NB UVB had an effect on the percentage of FoxP3(+)CD3(+) T cells.

KW - Adult

KW - Dermatitis, Atopic

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Severity of Illness Index

KW - Single-Blind Method

KW - Ultraviolet Therapy

KW - Young Adult

U2 - 10.1016/j.jaad.2008.08.048

DO - 10.1016/j.jaad.2008.08.048

M3 - Article

C2 - 19103360

SN - 0190-9622

VL - 60

SP - 77

EP - 84

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 1

ER -

Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis

Abstract

Keywords

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