Myoepithelial Tumors of Bone

Wangzhao Song; Uta Flucke; Albert J H Suurmeijer

doi:10.1016/j.path.2017.04.010

Myoepithelial Tumors of Bone

Wangzhao Song, Uta Flucke, Albert J H Suurmeijer

Research output: Contribution to journal › Review article › peer-review

Abstract

Myoepithelial tumors (METs) of bone (BMETs) are a rare but distinct tumor entity. METs that are cytologically benign are termed myoepitheliomas; METs with malignant histologic features are called myoepithelial carcinomas. BMETs have a wide age range, may involve any part of the skeleton, and have a variable spindle cell and epithelioid morphology. Bone tumors to be considered in the differential diagnosis are discussed. Additional techniques are indispensable to correctly diagnose BMETs. By immunohistochemistry, BMETs often express cytokeratins and/or EMA together with S100, GFAP, or calponin. Half of BMETs harbor EWSR1 (or rare FUS) gene rearrangements with different gene partners.

Original language	English
Pages (from-to)	657-674
Number of pages	18
Journal	Surgical Pathology Clinics
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.path.2017.04.010
Publication status	Published - Sept 2017
Externally published	Yes

Keywords

Bone
EWSR1
FUS
Fusion gene
Immunohistochemistry
Myoepithelial carcinoma
Myoepithelioma
Pathology

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10.1016/j.path.2017.04.010

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title = "Myoepithelial Tumors of Bone",

abstract = "Myoepithelial tumors (METs) of bone (BMETs) are a rare but distinct tumor entity. METs that are cytologically benign are termed myoepitheliomas; METs with malignant histologic features are called myoepithelial carcinomas. BMETs have a wide age range, may involve any part of the skeleton, and have a variable spindle cell and epithelioid morphology. Bone tumors to be considered in the differential diagnosis are discussed. Additional techniques are indispensable to correctly diagnose BMETs. By immunohistochemistry, BMETs often express cytokeratins and/or EMA together with S100, GFAP, or calponin. Half of BMETs harbor EWSR1 (or rare FUS) gene rearrangements with different gene partners.",

keywords = "Bone, EWSR1, FUS, Fusion gene, Immunohistochemistry, Myoepithelial carcinoma, Myoepithelioma, Pathology",

author = "Wangzhao Song and Uta Flucke and Suurmeijer, {Albert J H}",

year = "2017",

month = sep,

doi = "10.1016/j.path.2017.04.010",

language = "English",

volume = "10",

pages = "657--674",

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TY - JOUR

T1 - Myoepithelial Tumors of Bone

AU - Song, Wangzhao

AU - Flucke, Uta

AU - Suurmeijer, Albert J H

PY - 2017/9

Y1 - 2017/9

N2 - Myoepithelial tumors (METs) of bone (BMETs) are a rare but distinct tumor entity. METs that are cytologically benign are termed myoepitheliomas; METs with malignant histologic features are called myoepithelial carcinomas. BMETs have a wide age range, may involve any part of the skeleton, and have a variable spindle cell and epithelioid morphology. Bone tumors to be considered in the differential diagnosis are discussed. Additional techniques are indispensable to correctly diagnose BMETs. By immunohistochemistry, BMETs often express cytokeratins and/or EMA together with S100, GFAP, or calponin. Half of BMETs harbor EWSR1 (or rare FUS) gene rearrangements with different gene partners.

AB - Myoepithelial tumors (METs) of bone (BMETs) are a rare but distinct tumor entity. METs that are cytologically benign are termed myoepitheliomas; METs with malignant histologic features are called myoepithelial carcinomas. BMETs have a wide age range, may involve any part of the skeleton, and have a variable spindle cell and epithelioid morphology. Bone tumors to be considered in the differential diagnosis are discussed. Additional techniques are indispensable to correctly diagnose BMETs. By immunohistochemistry, BMETs often express cytokeratins and/or EMA together with S100, GFAP, or calponin. Half of BMETs harbor EWSR1 (or rare FUS) gene rearrangements with different gene partners.

KW - Bone

KW - EWSR1

KW - FUS

KW - Fusion gene

KW - Immunohistochemistry

KW - Myoepithelial carcinoma

KW - Myoepithelioma

KW - Pathology

UR - http://www.scopus.com/inward/record.url?scp=85021324091&partnerID=8YFLogxK

U2 - 10.1016/j.path.2017.04.010

DO - 10.1016/j.path.2017.04.010

M3 - Review article

C2 - 28797507

AN - SCOPUS:85021324091

SN - 1875-9181

VL - 10

SP - 657

EP - 674

JO - Surgical Pathology Clinics

JF - Surgical Pathology Clinics

IS - 3

ER -

Myoepithelial Tumors of Bone

Abstract

Keywords

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